Multiple Myeloma Presenting in Patients Younger than 50 Years of Age: A Single Institution Experience.

Acta Haematologica
Adrian DuekMerav Leiba

Abstract

Multiple myeloma (MM) is uncommon in persons younger than 50 years of age. The presenting features in this age group are unclear. We analyzed a cohort of patients <50 years of age with MM treated in our center. Twenty-three patients at a median age of 41.5 years (range 27-49) were analyzed. Patients presented at International Staging System (ISS) I-II (79%), had high frequency of bone lytic lesions (89%), extramedullary disease (26%), light-chain myeloma (45%), and translocation t(11;14) (68%). The subpopulation of patients carrying t(11;14) were younger (p = 0.025). This subgroup had higher bone marrow infiltration of plasma cells (75 vs. 47.5%), higher incidence of proteinuria (2.9 vs. 0.19 g/day), and poorer response to therapy: 85.7% of patients achieving complete/very good partial remission after induction therapy did not have t(11;14). A trend toward inferior progression-free survival (PFS) was observed in patients with t(11; 14) compared to patients without this translocation (median PFS 18 and 36 months, respectively). Translocation t(11; 14) seems to be more prevalent in young myeloma patients. Young myeloma patients and especially those who harbor translocation t(11; 14) may represent a distinct clinical entity that c...Continue Reading

References

Apr 16, 1998·Annals of Hematology·A CorsoC Bernasconi
Feb 22, 2002·The New England Journal of Medicine·Robert A KyleL Joseph Melton
Jan 17, 2003·Mayo Clinic Proceedings·Robert A KylePhilip R Greipp
Apr 6, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Philip R GreippJan Westin
Mar 31, 2006·The New England Journal of Medicine·Robert A KyleL Joseph Melton
Jul 21, 2006·Leukemia·B G M DurieUNKNOWN International Myeloma Working Group
Feb 24, 2009·Blood·Brendan M WeissW Michael Kuehl
Jun 23, 2009·Lancet·Marc S RaabKenneth C Anderson
Sep 30, 2009·Genes, Chromosomes & Cancer·Luba TrakhtenbrotNinette Amariglio
Sep 9, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joan BladéRay Powles
Feb 2, 2013·British Journal of Haematology·Lisa BilleckeGeorgia Schilling
Oct 23, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kai NebenDirk Hose
Dec 3, 2014·The Lancet Oncology·S Vincent RajkumarJesus F San Miguel
Mar 18, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tilmann BochtlerStefan O Schönland
Apr 4, 2015·Blood·S Vincent RajkumarMaría-Victoria Mateos
May 7, 2016·Genes, Chromosomes & Cancer·Merav LeibaLuba Trakhtenbrot
Jun 29, 2017·Leukemia·A LakshmanS K Kumar
Aug 23, 2018·Frontiers in Endocrinology·Barry G Hansford, Rebecca Silbermann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.