PMID: 8068084Apr 16, 1994Paper

Multiple myeloma

BMJ : British Medical Journal
I C MacLennanJ Dunn

Abstract

Multiple myeloma occurs in over 2000 new patients in England and Wales each year. It presents most frequently as bone pain and patients tend to become dehydrated and may develop renal failure. No available treatment is curative, but about two thirds of patients achieve a stable response with low dose combination chemotherapy. Combination chemotherapy including doxorubicin and carmustine with the alkylating agents cyclophosphamide and melphalan achieve a higher stable response rate than conventional treatment with melphalan and prednisone without additional haematological toxicity. These responses are associated with loss of bone pain and patients remain symptom free for months without further treatment. Relapse occurs on average in a little under two years and, though second responses are frequently obtained, the disease eventually becomes refractory. This paper looks at who should be treated and the benefits that may be expected from the treatments available.

Citations

Aug 19, 2008·Pediatric Emergency Care·William P MeehanVincent W Chiang
Sep 5, 2003·International Journal of Hematology·Franco SilvestrisFranco Dammacco
Nov 2, 2014·Asia-Pacific Journal of Clinical Oncology·Baidarbhi ChakrabortyBinita Goswami
Mar 1, 1997·Postgraduate Medical Journal·A OlujohungbeJ Holmes
Jan 19, 2005·European Journal of Haematology·C A Uyl-de GrootP C Huijgens
Oct 29, 2002·Leukemia & Lymphoma·Marco TucciFranco Dammacco
Jan 7, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marion Haubitz, Dietrich Peest
Dec 1, 1994·British Journal of Haematology·J A Child
Jun 5, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andy C RawstronRoger G Owen
Mar 17, 2021·Hematological Oncology·Teruhito TakakuwaItaru Matsumura

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