Multiple needle-pass percutaneous testicular sperm aspiration as first-line treatment in azoospermic men

Andrology
C F S JensenJ Sonksen

Abstract

Percutaneous testicular sperm aspiration (TESA) has been known for decades as a simple, minimally invasive approach to sperm retrieval in azoospermic men. Because of lower reported sperm retrieval rates (SRR) when compared with microdissection testicular sperm extraction (mTESE), many centers now use mTESE as the first choice for retrieving spermatozoa in nonobstructive azoospermia (NOA). Objectives of this study were to evaluate the outcome and safety of TESA and mTESE in the treatment of azoospermia and to investigate the usefulness of a prognostic TESA to individualize protocols for couples and limit the use of invasive testicular procedures. IRB approval was obtained to retrospectively evaluate 208 patients undergoing multiple needle-pass TESA between 1999 and 2014. Prognostic TESA was performed on 125 men with NOA and 82 with obstructive azoospermia (OA). Nine NOA men and 31 OA men with previously demonstrated spermatozoa had a subsequent therapeutic TESA while nine NOA men with a failed TESA proceeded to mTESE. Main outcome measures were complication rates and SRR. SRR of the prognostic TESA was 30% (38/125) for NOA men and 100% (82/82) for OA men. Eight/nine NOA men and 31/31 OA men had spermatozoa found for intracytopla...Continue Reading

Associated Clinical Trials

References

Jul 1, 1989·The Journal of Urology·J P JarowL I Lipshultz
Jul 1, 1982·Forensic Science International : Synergy·G M Willott
Jul 1, 1998·Human Reproduction·B RosenlundT Hillensjö
Apr 18, 2002·Journal of Assisted Reproduction and Genetics·M L WindtJ P van der Merwe
Mar 27, 2007·The Journal of Urology·Ranjith Ramasamy, Peter N Schlegel
Sep 8, 2007·International Journal of Andrology·S El-HaggarA Abdel Hadi
Oct 9, 2007·Current Opinion in Urology·Moshe WaldCraig S Niederberger
Oct 14, 2008·Acta Obstetricia Et Gynecologica Scandinavica·Juul HouwenErling Ekerhovd
Feb 28, 2009·Seminars in Reproductive Medicine·Peter N Schlegel
Jan 25, 2011·Asian Journal of Andrology·Monika E Beliveau, Paul J Turek
Aug 4, 2011·Journal of Clinical Medicine Research·Ibrahim Fathi GhalayiniYazan Haddad
Dec 14, 2011·Asian Journal of Andrology·Gert R DohleNiels J van Casteren
Dec 18, 2012·Asian Journal of Andrology·Ali A Dabaja, Peter N Schlegel
Mar 27, 2013·Clinics·Ahmet Gudeloglu, Sijo J Parekattil
Mar 27, 2013·Clinics·Sidney Glina, Marcelo Vieira
Nov 30, 2013·The Urologic Clinics of North America·Matthew S Wosnitzer, Marc Goldstein

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