Multiple-organ effect of normobaric hyperoxia in neonatal rats

Journal of Critical Care
D TorbatiBalagangadhar R Totapally

Abstract

Prolonged exposure to normobaric hyperoxia (NH) is associated with blood leukocyte activation and sequestration in the lung. Whether NH-induced leukocyte activation and sequestration can affect extrapulmonary organs or blood cellular profile has not been systematically investigated. We studied simultaneous changes in blood cellular profile and pulmonary, renal, and intestinal histology during NH and after return to air breathing ("weaning"). One-day-old rats were exposed to 2 to 4 days of NH (FiO2 >0.98) or normoxia (FiO2 = 0.21), with or without weaning. Pups were then euthanized and 100 microL of blood was collected (cardiac puncture) for differential white blood cells analysis (n = 12 per group). The lungs, a piece of distal ileum, and the left kidney were removed for histologic evaluation. Both NH and weaning generated significant increases in blood neutrophil count, whereas lymphocyte population was significantly increased only after weaning (P < .05; analysis of variance with Bonferroni correction for multiple comparisons). Normobaric hyperoxia created mild increases in the renal tubular necrosis, dilation, regeneration, and interstitial inflammation. A significant increase in the intestinal serosal and submucosal vasodia...Continue Reading

References

Nov 1, 1978·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·L FrankR J Roberts
Mar 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M K ParkL Marzella
Jan 1, 1991·Free Radical Biology & Medicine·L Frank
Dec 1, 1991·Journal of Applied Physiology·P J FracicaJ D Crapo
Sep 1, 1987·The American Review of Respiratory Disease·R de los SantosJ I Peters
Apr 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·F SchaffnerF Ulvedal
Aug 1, 1984·The American Review of Respiratory Disease·M GlassA B Fisher
Oct 13, 1983·The New England Journal of Medicine·W B DavisR G Crystal
Jan 1, 1982·Biology of the Neonate·S H ErdmanG Rothstein
Feb 1, 1997·Pediatric Research·L TaittonenM Nuutinen
Jun 1, 1997·Journal of Critical Care·S G SimonsonC A Piantadosi
Nov 14, 1997·Experimental Lung Research·C J JohnstonJ N Finkelstein
May 20, 1998·Archives of Toxicology·R R VangalaH Topp
Oct 8, 1998·American Journal of Respiratory Cell and Molecular Biology·B PiedboeufP Petrov
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·A H Jobe, E Bancalari
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·S H Abman
Mar 29, 2002·American Journal of Respiratory Cell and Molecular Biology·Richard L AutenS Nicholas Mason
Apr 18, 2003·Frontiers in Bioscience : a Journal and Virtual Library·Ashima Madan, John S Penn
May 23, 2003·American Journal of Respiratory Cell and Molecular Biology·Sandra PerkowskiSteven M Albelda
Jun 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·C E MENGELB D HORTON
Mar 6, 2004·Seminars in Neonatology : SN·Lois E H Smith
Jun 9, 2004·Clinics in Perinatology·Joyce M Koenig, Mervin C Yoder
Mar 1, 1987·Journal of Anesthesia·M KonnoR Wakusawa
Aug 25, 2004·Journal of the European Academy of Dermatology and Venereology : JEADV·T GambichlerK Hoffmann
Jun 30, 1932·The Journal of Experimental Medicine·F J SmithC K Drinker
Jun 26, 2010·Journal of Applied Physiology·Ryan W BavisDonna A Rampersad

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Citations

Dec 25, 2009·Lung·Matthew J MacCarrickBalagangadhar R Totapally
Jan 13, 2015·Pediatrics and Neonatology·Jiunn-Song JiangChung-Ming Chen
Nov 19, 2008·The Journal of Pediatrics·Georg M SchmölzerColin J Morley
Jun 9, 2016·Experimental and Molecular Pathology·Chung-Ming Chen, Hsiu-Chu Chou
Oct 27, 2016·Pediatric Research·Colby L Day, Rita M Ryan
Jan 18, 2019·Journal of Cellular Physiology·Jennifer L RodgersSiva K Panguluri
Oct 28, 2017·Experimental and Therapeutic Medicine·Min ZhaoDongyan Liu
May 16, 2019·Pediatric Research·Chung-Ming Chen, Hsiu-Chu Chou
Jul 6, 2018·International Journal of Molecular Sciences·Jochen HinkelbeinAndreas Hohn
Nov 28, 2019·International Journal of Preventive Medicine·Ismail Kursad Gokce, Serife Suna Oguz
Nov 16, 2017·International Journal of Molecular Medicine·Min ZhaoDongyan Liu
Jan 12, 2021·BioMed Research International·D Y LiuS Y Sun
Jun 17, 2019·Experimental and Molecular Pathology·Hsiu-Chu Chou, Chung-Ming Chen

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