Multiple orphan nuclear receptors converge to regulate rat P450c17 gene transcription: novel mechanisms for orphan nuclear receptor action

Molecular Endocrinology
P Zhang, S H Mellon

Abstract

The orphan nuclear receptor steroidogenic factor-1 (SF-1) plays a key role in regulating the expression of the rat P450c17 gene in testicular Leydig and in adrenocortical cells. Other DNA sequences, not bound by SF-1, are also involved in transcriptional regulation of the rat P450c17 gene in both cell types. The region from -447/-399 or from -447/-419 increased both basal and cAMP-induced transcription, and the region from -418/-399 increased basal transcription to a greater extent than the intact -447/-399 DNA. The -447/-399 DNA sequence contains three imperfect copies of the orphan nuclear receptor-binding motif, AGGTCA, and at least three known orphan nuclear receptors, chicken ovalbumin upstream promoter transcription factor (COUP-TF), SF-1, and an early response gene induced by nerve growth factor (NGFI-B), bind to -447/-399 DNA. The AGGTCA triad is bound by one set of nuclear proteins when these three elements are colinear and is bound by a different set of proteins when these elements are separated. When the elements are separated, COUP-TF no longer binds, and the region -418/-399 is bound by a protein that greatly stimulates basal transcription. The region -447/-419 is bound by two different proteins that mediate both b...Continue Reading

Citations

Apr 6, 2000·The Biochemical Journal·P Honkakoski, M Negishi
Sep 30, 2010·Physiological Genomics·Damian G RomeroCelso E Gomez-Sanchez
Oct 4, 2008·Endocrinology·Yimin ShiSynthia H Mellon
Feb 20, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Martha Z Carletti, Lane K Christenson
Feb 21, 2013·Reproductive Biology and Endocrinology : RB&E·Boqun XuJiayin Liu
May 12, 2012·Biochemical and Biophysical Research Communications·Chin-Hee SongKeesook Lee
Jul 21, 2009·Molecular and Cellular Endocrinology·Erling A HoivikMarit Bakke
Jun 29, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Carole R Mendelson, Amrita Kamat
Jun 20, 2003·Annals of the New York Academy of Sciences·Michelle L BlandHolly A Ingraham
May 7, 2009·Annals of the New York Academy of Sciences·Jacques J TremblayEric Laguë
Nov 18, 2005·Biochemical Pharmacology·Kentaro MoritaMakoto Makishima
Feb 12, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Qing LiuJianchun Bian
Aug 6, 1999·Frontiers in Neuroendocrinology·G D Hammer, H A Ingraham
Jul 6, 2016·Frontiers in Endocrinology·Aurélia E LewisMarit Bakke
Oct 25, 2016·International Journal of Molecular Sciences·Siliang XuShi-Wen Jiang
Nov 12, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Shi-Wen JiangJiayin Liu
Apr 9, 2010·Biology of Reproduction·Luc J Martin, Jacques J Tremblay
Oct 21, 2005·Biology of Reproduction·Nicholas M RobertJacques J Tremblay
May 29, 2015·Biology of Reproduction·Mickaël Di-LuoffoJacques J Tremblay
Aug 12, 2015·Scientific Reports·Imteyaz QamarArul Narayanasamy
Mar 23, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Fan HuLingqiang Zhang
Jul 9, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Margaret M HinshelwoodCarole R Mendelson
Feb 13, 2001·Endocrine Reviews·A LacroixP Hamet
Oct 26, 1999·Endocrine Reviews·V Giguère
Aug 14, 1999·Molecular Endocrinology·K KawabeK Morohashi
Mar 1, 2007·Physiological Genomics·Damian G RomeroCelso E Gomez-Sanchez
Jun 6, 2014·Archives of Environmental Contamination and Toxicology·A H ShanthanagoudaJ G Patil
Mar 24, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Emilia PrzygrodzkaMonika M Kaczmarek
Nov 2, 2006·Endocrine Reviews·Carlos StoccoGeula Gibori

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