Multiple outbreaks of acute hemorrhagic conjunctivitis due to a variant of coxsackievirus A24: Guangdong, China, 2007

Journal of Medical Virology
De WuHuan-ying Zhen

Abstract

Acute hemorrhagic conjunctivitis (AHC) is usually caused by enterovirus 70, coxsackievirus A24(CA24v) and adenoviruses. Several outbreaks of AHC caused by a CA24v have occurred since it was imported into China in 1971. Multiple outbreaks of AHC reappeared in 10 cities of Guangdong during June to November in 2007. The epidemic began in the June, and spread extensively, with a peak in the September. A total of 31,659 cases were reported to center for disease control and prevention of Guangdong, it was estimated that the number of actual AHC was >200 thousands. Forty conjunctival swab specimens were collected from the cases diagnosed clinically with AHC. (RT)-PCR testing on these conjunctival specimens revealed the presence of an enterovirus, and this was confirmed by 16 isolates. We demonstrated the most likely etiological agent for the multiple outbreaks was a variant of coxsackievirus A24 by molecular typing using a partial VP1 sequence. Sequence comparison and phylogenetic analyses of the VP1 and 3Cpro gene regions were performed by Neighbor-joining method, the strains from different outbreaks and different geographical areas within Guangdong had no sequence divergence in 2007. The representative isolates from mainland of Chin...Continue Reading

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Citations

Apr 27, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jooeun LeeHungwon Tchah
Oct 20, 2009·Médecine et maladies infectieuses·N LévêqueJ-J Chomel
Jun 26, 2009·Current Medical Research and Opinion·Terrence P O'BrienMichael B Raizman
Mar 5, 2016·Archives of Virology·Yilin ZhaoShaohui Ma
May 29, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Pei-Yu ChuKuei-Hsiang Lin
Sep 11, 2013·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Judith A Guzman-CottrillUNKNOWN Society for Healthcare Epidemiology of America
Jun 3, 2021·Clinical Microbiology Reviews·Sixto M LealPeter H Gilligan

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