Multiple, parallel cellular suicide mechanisms participate in photoreceptor cell death

Experimental Eye Research
Heather R LohrBärbel Rohrer

Abstract

Photoreceptor degeneration in human photoreceptor dystrophies and in the relevant animal models has been thought to be executed by one common mechanism -- caspase-mediated apoptosis. However, recent experiments have challenged this concept. In previous experiments, analyzing gene expression in the degenerating rd/rd mouse retina, we have suggested that the gene defect leads to oxidative stress and altered metabolism, which may induce caspase-dependent and caspase-independent cell death mechanisms such as the activation of cystein-proteases, lysosomal proteases, autophagy and complement-mediated lysis. In this study we asked two questions. First, whether a temporal analysis of these different mechanisms during the course of degeneration would enable us to establish a causal relationship between these events; and second, whether photoreceptor degeneration in different models of photoreceptor dystrophies occurs by activating the same mechanisms. Three models of photoreceptor degeneration were chosen in which photoreceptor degeneration is caused by different events: the rd/rd mouse (calcium overload); the rds/rds mouse (structural defect); and light-damage (LD; oxidative stress). Marker genes were selected for the identified proces...Continue Reading

References

Jan 1, 1991·Annals of the New York Academy of Sciences·M M LaVailR H Steinberg
Jan 1, 1988·Methods in Enzymology·P ArnaudL Miribel
Jul 1, 1974·The Journal of Comparative Neurology·J C BlanksR N Lolley
Mar 25, 1968·Biochimica Et Biophysica Acta·J A McDermottE Frieden
Jun 1, 1981·The Journal of General Physiology·B S Winkler
Nov 1, 1984·The Journal of Comparative Neurology·R W Young
Nov 1, 1980·The Journal of Comparative Neurology·S SanyalR K Hawkins
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·A S PolansG Adamus
Jan 1, 1994·Springer Seminars in Immunopathology·B P Morgan, S Meri
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·C Portera-CailliauR Adler
Jul 17, 1997·Nature·Q L DeverauxJ C Reed
Aug 1, 1997·Trends in Biochemical Sciences·D W Nicholson, N A Thornberry
Jan 31, 1998·Journal of Molecular Biology·H Liang, S W Fesik
Apr 29, 1998·American Journal of Human Genetics·G H Travis
Oct 26, 1999·Progress in Retinal and Eye Research·J StoneJ Peér
Jun 20, 2000·Neurobiology of Aging·H AkiyamaT Wyss-Coray
Sep 16, 2000·Biochemical Society Symposium·P NicoteraE Ferrando-May
Dec 2, 2000·Science·D J Klionsky, S D Emr
Jun 19, 2001·International Journal of Cancer. Journal International Du Cancer·M MitasD J Cole
Jul 20, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·E A Pierce
Apr 6, 2002·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Katsuhiko YoshizawaAiro Tsubura
Sep 10, 2002·Nature Genetics·Wenshan HaoJanis Lem
Feb 19, 2003·Experimental Eye Research·B RohrerL F Reichardt
Aug 15, 2003·The Journal of Biological Chemistry·Cinthya A GuimarãesRafael Linden
Oct 7, 2003·Annual Review of Neuroscience·Laura R PacioneRoderick R McInnes
Oct 17, 2003·Genes & Development·Jerry M Adams
Oct 28, 2003·Investigative Ophthalmology & Visual Science·Feng LiRobert E Anderson
Jan 28, 2004·Cell·Nika N Danial, Stanley J Korsmeyer
Apr 8, 2004·Developmental Cell·Beth Levine, Daniel J Klionsky
Apr 14, 2004·Archives of Ophthalmology·Marco A Zarbin
Apr 28, 2004·Experimental Eye Research·Edward H HughesAndrew D Dick
Jun 23, 2004·The Journal of Biological Chemistry·Ashish K Sharma, Baerbel Rohrer

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Citations

Oct 24, 2012·Journal of Bioenergetics and Biomembranes·Nathan R PerronBärbel Rohrer
Mar 23, 2011·Expert Reviews in Molecular Medicine·Maria Xilouri, Leonidas Stefanis
Feb 9, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Bärbel RohrerV Michael Holers
Sep 1, 2011·Retina·Sylvie Eigeldinger-BerthouGian-Marco Sarra
May 26, 2007·Investigative Ophthalmology & Visual Science·R Brooks WilsonBärbel Rohrer
Jan 27, 2010·Journal of Lipid Research·Nora P RotsteinO Lorena German
Dec 24, 2013·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Shinichi FukudaTetsuro Oshika
Nov 5, 2008·Molecular Neurobiology·Javier Sancho-PelluzFrançois Paquet-Durand
Dec 24, 2013·Environmental Health Perspectives·Yu-Man ShangLi-Ling Lee
Jan 1, 2014·Journal of Clinical Medicine·Alasdair WarwickAndrew Lotery
Jan 17, 2016·Progress in Retinal and Eye Research·Michael W StuckMuna I Naash
Nov 26, 2009·Experimental Eye Research·Ulrica Englund-JohanssonKjell Johansson
Jun 23, 2009·The American Journal of Pathology·Megan PodowskiEnid R Neptune
May 27, 2008·Brain Research Bulletin·Belmira Lara da Silveira Andrade da CostaNeville N Osborne
Feb 25, 2009·Journal of Neuroscience Research·Juliana Adão-NovaesAlfred Sholl-Franco
Feb 4, 2009·Journal of Neurochemistry·François Paquet-DurandPer Ekström
Oct 16, 2008·Journal of Neuroscience Research·Carolina E AbrahanNora P Rotstein
Jun 8, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Ruth Bejarano-EscobarGervasio Martín-Partido
Dec 19, 2009·The Journal of Comparative Neurology·Ana M SantosMiguel A Cuadros
Sep 6, 2006·Experimental Eye Research·Rico FriggChristian Grimm
Jul 24, 2015·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Olga Lorena GermanNora P Rotstein
Jun 28, 2014·Biochemical and Biophysical Research Communications·Tian-Zi ZhangGuang-Yu Li
Apr 16, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Miriam ReisenhoferVolker Enzmann
May 9, 2014·Experimental Eye Research·Laura S FrostKathleen Boesze-Battaglia
Nov 14, 2014·PloS One·Blanca Arango-GonzalezFrançois Paquet-Durand

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