Multiple Particle Manipulation under Dielectrophoresis Effect: Modeling and Experiments

Langmuir : the ACS Journal of Surfaces and Colloids
Waqas WaheedEiyad Abu-Nada

Abstract

The dissipative particle dynamics (DPD) technique was employed to design multiple microfluidic devices for investigating the motion of bioparticles at low Reynolds numbers. A DPD in-house FORTRAN code was developed to simulate the trajectories of two microparticles in the presence of hydrodynamic and transverse deflecting force fields via considering interparticle interaction forces. The particle-particle interactions were described by using a simplified version of the Morse potential. The transverse deflecting force considered in this microfluidic application was the dielectrophoresis (DEP) force. Multiple microfluidic devices with different configurations of microelectrodes were numerically designed to investigate the dielectrophoretic behavior of bioparticles for their trajectories and the focusing of bioparticles into a single stream in the middle of the microchannel. The DPD simulation results were verified and validated against previously reported numerical and experimental works in the literature. The computationally designed microdevices were fabricated by employing standard lithographic techniques, and experiments were conducted via taking red blood cells as the representative bioparticles. The experimental results for...Continue Reading

References

Sep 1, 1971·Biophysical Journal·H A Pohl, J S Crane
Aug 1, 1997·Biophysical Journal·Y HuangP R Gascoyne
May 26, 1998·Analytical Chemistry·S FiedlerG Fuhr
Jul 17, 1998·Current Opinion in Chemical Biology·M U KoppA Manz
May 18, 2000·Analytical Chemistry·D Figeys, D Pinto
Nov 5, 2002·Biophysical Journal·Björn Neu, Herbert J Meiselman
Jan 31, 2006·IEE Proceedings. Nanobiotechnology·D HolmesH Morgan
Mar 31, 2006·Lab on a Chip·Adam RosenthalJoel Voldman
Nov 13, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Tao SunNicolas G Green
Jun 3, 2008·The Journal of Physical Chemistry. B·Manuel J MendesMatteo Pasquali
Jun 19, 2008·Analytical Chemistry·Chin Hock KuaKamal Youcef-Toumi
Jul 3, 2008·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·N FilipovicA Tsuda
Jun 9, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Hiromi SakaiEishun Tsuchida
Sep 28, 2010·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Eiyad Abu-Nada
Mar 25, 2011·Lab on a Chip·Suresh NeethirajanFrancis Lin
Aug 9, 2011·Electrophoresis·Nadia M Jesús-Pérez, Blanca H Lapizco-Encinas
Jan 26, 2013·Journal of Colloid and Interface Science·Mohammad Robiul HossanPrashanta Dutta
May 15, 2013·Biomechanics and Modeling in Mechanobiology·Dmitry A FedosovGerhard Gompper
Dec 18, 2013·Electrophoresis·Talukder Z JuberyPrashanta Dutta
Mar 5, 2014·Cell Biochemistry and Biophysics·Hua LiK Y Lam
Apr 4, 2014·Soft Matter·Dmitry A Fedosov, Gerhard Gompper
Dec 27, 2015·Journal of Biomechanics·Ting YeChwee Teck Lim
Jun 21, 2016·Journal of Separation Science·Bobby MathewIon Stiharu
Oct 27, 2016·The Journal of Chemical Physics·Mingge DengGeorge Em Karniadakis
Apr 24, 2017·The Journal of Chemical Physics·Pep Español, Patrick B Warren
Feb 28, 2018·Advanced Materials·Sherjeel M KhanMuhammad M Hussain
Apr 27, 2018·Medical & Biological Engineering & Computing·Zelin Xu, Clement Kleinstreuer
May 8, 2018·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Waqas WaheedEiyad Abu-Nada

❮ Previous
Next ❯

Citations

Jan 2, 2021·Journal of Chromatography. a·Waqas WaheedEiyad Abu-Nada
Aug 3, 2021·Journal of Applied Physics·Mohammad Asif ZamanLambertus Hesselink

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.