Multiple pathways for noxious information in the human spinal cord

Pain
Takeshi TsujiRyusuke Kakigi

Abstract

To investigate the pathways of noxious information in the spinal cord in humans, we recorded cortical potentials following the stimulation of A-delta fibers using a YAG laser applied to two cutaneous points on the back at the C7 and Th10 level, 4cm to the right of the vertebral spinous process. A multiple source analysis showed that four sources were activated; the primary somatosensory cortex (SI), bilateral parasylvian region (Parasylvian), and cingulate cortex. The activity of the cingulate cortex had two components (N2/P2). The mean peak latencies of the activities obtained by C7 and Th10 stimulation were 166.9 and 186.0 ms (SI), 144.3 and 176.8 ms (contralateral Parasylvian), 152.7 and 185.5 ms (ipsilateral Parasylvian), 186.2 and 215.8 ms (N2), and 303.0 and 332.3 ms (P2). Estimated spinal conduction velocities (CVs) of the respective activities were 16.8, 9.3, 8.7, 10.1 and 10.7 m/s. CV of SI was significantly faster than the others (P<0.05). Therefore, our results suggested that noxious signals were conveyed through at least two distinct pathways of the spinal cord probably reaching distinct groups of thalamic nuclei. Further studies are required to clarify the functional significance of these two pathways.

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Citations

Mar 29, 2007·Experimental Brain Research·Xiaohong WangRyusuke Kakigi
Nov 3, 2012·Interdisciplinary Perspectives on Infectious Diseases·Prachi Bhargava, Rajni Singh
Nov 6, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ceferino MaestuAngel Nevado
Jun 7, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Marina de TommasoZaza Katzarava
May 24, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·M ValerianiC Vollono
May 20, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·G CruccuL Garcia-Larrea
Mar 21, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Massimiliano ValerianiPietro Tonali
Jun 20, 2006·Pain·Rolf-Detlef Treede, Frederick A Lenz

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