PMID: 8952038Nov 1, 1996Paper

Multiple peripheral nerve sheath tumors in the small intestine of a horse

Veterinary Pathology
N KirchhofW Baumgärtner

Abstract

Multiple neurofibromas, schwannomas, and hyperplastic enteric plexuses were observed in the distal jejunum and ileum of a 6-year-old pinto gelding. The animal was presented because of an acute episode of colic. Three meters of distal small intestine, partially incarcerated in the epiploic foramen, were surgically removed. Numerous tumor nodules up to 10 mm in diameter were found adjacent to a Meckel's diverticulum, predominantly located in the subserosa of a hypertrophic segment. Histologically, tumors were well demarcated and composed of interlacing fascicles formed by spindloid cells. Adjacent enteric plexuses were hyperplastic. Immunohistochemically, all tumors were positive for vimentin and S-100. Desmin immunoreactivity was only observed in larger tumors (> 500 microns). Glial fibrillary acid protein was demonstrated nearly exclusively in smaller ones. Immunostaining for neurofilament was restricted to entrapped ganglion cells. Based on conventional light microscopic examination and immunohistochemical evaluation, the lesion was diagnosed as multiple benign peripheral nerve sheath tumors in the small intestine.

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Citations

Jan 8, 2008·Journal of the American Animal Hospital Association·Coretta C PattersonBarbara Steficek
Sep 30, 2010·Journal of Comparative Pathology·J-W ParkD-Y Kim
May 30, 2009·Journal of Comparative Pathology·W BergmannM Welle
Apr 18, 2006·Journal of Comparative Pathology·E Beytut
Sep 27, 2015·Acta Veterinaria Scandinavica·Talita P ResendeRoberto M C Guedes
Jan 10, 2008·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Ben P R SturgeonKenneth C Smith
May 25, 2012·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Paul R FacemireShelley P Honnold
Mar 31, 2001·Veterinary Pathology·S HafnerT King
May 4, 2017·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Lauren Himmel, Rachel Cianciolo
Dec 6, 2001·Veterinary Pathology·G StoicaH T Kim
Dec 6, 2001·Veterinary Pathology·F Del PieroE A Blomme
Jul 17, 2010·Veterinary Pathology·L BogaertK Chiers
Sep 12, 2007·Veterinary Pathology·D SchaudienW Baumgärtner
Jun 18, 2017·JFMS Open Reports·Ariadna RibasRoberta Rasotto
Oct 17, 2020·Journal of Equine Science·Riccardo RinnovatiMaria Morini

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