Multiple Phases of Climbing Fiber Synapse Elimination in the Developing Cerebellum

The Cerebellum
M KanoMasahiko Watanabe

Abstract

Functional neural circuits in the mature animals are shaped during postnatal development by elimination of unnecessary synapses and strengthening of necessary ones among redundant synaptic connections formed transiently around birth. In the cerebellum of neonatal rodents, excitatory synapses are formed on the somata of Purkinje cells (PCs) by climbing fibers (CFs) that originate from neurons in the contralateral inferior olive. Each PC receives inputs from multiple (~ five) CFs that have about equal synaptic strengths. Subsequently, a single CF selectively becomes stronger relative to the other CFs during the first postnatal week. Then, from around postnatal day 9 (P9), only the strongest CF ("winner" CF) extends its synaptic territory along PC dendrites. In contrast, synapses of the weaker CFs ("loser" CFs) remain on the soma and the most proximal portion of the dendrite together with somatic synapses of the "winner" CF. These perisomatic CF synapses are eliminated progressively during the second and the third postnatal weeks. From P6 to P11, the elimination proceeds independently of the formation of the synapses on PC dendrites by parallel fibers (PFs). From P12 and thereafter, the elimination requires normal PF-PC synapse fo...Continue Reading

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Citations

Oct 5, 2018·The Cerebellum·Tomoo Hirano
Jul 28, 2019·The Journal of Experimental Medicine·Veronika KanaMiriam Merad
May 24, 2019·Frontiers in Cellular Neuroscience·Christina PätzJens Eilers
Aug 3, 2019·F1000Research·Masanobu Kano, Takaki Watanabe
Jan 27, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Yueh-Chi WuSheng-Han Kuo
Mar 11, 2021·Proceedings of the National Academy of Sciences of the United States of America·Mitsuharu Midorikawa, Mariko Miyata
Aug 31, 2020·Current Opinion in Physiology·Mark S BlumbergGreta Sokoloff
Jul 16, 2021·Frontiers in Neural Circuits·Esther Suk King LaiMasanobu Kano
Nov 4, 2021·The Journal of Comparative Neurology·Takanori IkenagaMasahiko Hibi
Dec 18, 2021·Frontiers in Cellular Neuroscience·Carlos Del PilarDavid Díaz

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