Multiple potential targets of opioids in the treatment of acute respiratory distress syndrome from COVID-19.

Journal of Cellular and Molecular Medicine
Cosmin Andrei CismaruIoana Berindan Neagoe

Abstract

COVID-19 can present with a variety of clinical features, ranging from asymptomatic or mild respiratory symptoms to fulminant acute respiratory distress syndrome (ARDS) depending on the host's immune responses and the extent of the associated pathologies. This implies that several measures need to be taken to limit severely impairing symptoms caused by viral-induced pathology in vital organs. Opioids are most exploited for their analgesic effects but their usage in the palliation of dyspnoea, immunomodulation and lysosomotropism may represent potential usages of opioids in COVID-19. Here, we describe the mechanisms involved in each of these potential usages, highlighting the benefits of using opioids in the treatment of ARDS from SARS-CoV-2 infection.

References

Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·S Ohkuma, B Poole
Jul 1, 1979·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·T V SantiagoN H Edelman
May 22, 1975·The New England Journal of Medicine·J V WeilI E Sodal
Sep 15, 1974·Biochemical Pharmacology·C de DuveF Van Hoof
Feb 1, 1982·Scientific American·K SimonsA Helenius
Dec 5, 1998·Microbiology and Molecular Biology Reviews : MMBR·H GaroffD J Opstelten
Mar 14, 2001·Drug and Alcohol Dependence·L McCarthyT J Rogers
May 24, 2005·Journal of Pain and Symptom Management·Gayle G Page
Jul 14, 2005·Expert Opinion on Drug Safety·Amit DindaPravin C Singhal
Sep 6, 2006·EMBO Reports·Eva SzegezdiAfshin Samali
Nov 23, 2006·Journal of Pharmaceutical Sciences·Allyn M Kaufmann, Jeffrey P Krise
Apr 3, 2007·Journal of Pain and Symptom Management·Katri Elina Clemens, Eberhard Klaschik
Oct 12, 2007·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Katri Elina Clemens, Eberhard Klaschik
Feb 12, 2008·American Journal of Respiratory and Critical Care Medicine·Andreas von LeupoldtChristian Büchel
Dec 19, 2008·Expert Review of Gastroenterology & Hepatology·Zahra Ghiassi-Nejad, Scott L Friedman
Jun 17, 2009·NeuroImage·Andreas von LeupoldtChristian Büchel
Jun 26, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kyle T S PattinsonRichard G Wise
Dec 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Pablo GastaminzaFrancis V Chisari
Jan 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Pavitra KannanMatthew D Hall
Apr 5, 2011·Journal of Pain and Symptom Management·David C CurrowAmy P Abernethy
Dec 15, 2011·Journal of Opioid Management·Eric Prommer
Feb 4, 2012·The Lancet Oncology·Augusto CaraceniUNKNOWN European Association for Palliative Care (EAPC)
Jul 4, 2012·Current Pharmaceutical Design·Merel BoomAlbert Dahan
Dec 12, 2012·Critical Care Medicine·Vahid SalimiLouis Bont
Jun 8, 2013·Journal of Pain and Symptom Management·Steffen T SimonRaymond Voltz
Oct 9, 2014·The American Journal of Hospice & Palliative Care·Miriam J JohnsonDavid C Currow
Oct 15, 2014·Journal of the National Comprehensive Cancer Network : JNCCN·Michael H LevyUNKNOWN National Comprehensive Cancer Network
Nov 27, 2014·The American Journal of Hospice & Palliative Care·G S PangA C P Yee
Sep 1, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M KlokeUNKNOWN ESMO Guidelines Committee
Feb 13, 2016·Nature Reviews. Drug Discovery·Alimuddin ZumlaKwok-Yung Yuen
Jul 26, 2016·Frontiers in Microbiology·Alireza TahamtanVahid Salimi
May 4, 2017·Seminars in Immunopathology·Rudragouda Channappanavar, Stanley Perlman
Sep 27, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rita J Valentino, Nora D Volkow
May 6, 2020·Antimicrobial Agents and Chemotherapy·Sangeun JeonSeungtaek Kim
May 16, 2020·Acta Neurologica Scandinavica·Abigail WhittakerAmer Harky
May 28, 2020·Journal of Neurology·Panagiotis Gklinos
Jun 6, 2020·Annals of the American Thoracic Society·Christopher M WorshamRichard M Schwartzstein

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