Multiple primary cancers with microsatellite instability: report of a case

Japanese Journal of Cancer Research : Gann
D IchikawaJ Inazawa

Abstract

We report here a patient who developed a variety of tumors both synchronously and metachronously over a 2-year period. The involved organs were the uterus, ureter, and small and large intestines. The patient underwent open surgery 3 times and polypectomies 6 times. Postoperative histopathologic analysis showed 2 adenomas and 8 carcinomas. Genetic analysis revealed microsatellite instabilities at the tested loci in all 10 tumors, indicating that replication errors played an essential role in the tumorigenesis. Early identification of microsatellite instability could be useful for predicting development of additional primary cancers.

References

May 1, 1992·Human Molecular Genetics·M H JonesY Nakamura
Oct 1, 1991·Japanese Journal of Cancer Research : Gann·A YanagisawaH Sugano
May 1, 1991·Diseases of the Colon and Rectum·H F VasenH T Lynch
Jul 16, 1985·Biochemical and Biophysical Research Communications·S E GoelzB Vogelstein
Jun 1, 1994·Nature Genetics·G GyapayJ Weissenbach
Jun 1, 1994·The American Journal of Medicine·P WatsonH T Lynch
Feb 3, 1994·Nature·F PalomboJ Hsuan
Mar 18, 1994·Science·N PapadopoulosM D Adams
May 7, 1993·Science·L A AaltonenS R Hamilton

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Citations

Sep 29, 1998·The Journal of Urology·F RabbaniP Russo

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