Multiple primary malignancies in patients with non-small cell lung cancer

Internal Medicine
Shiro FujitaNobuyuki Katakami

Abstract

Information regarding multiple primary malignancies is important, as it has the potential to clarify etiological factors and may indicate the need to refine patient follow-up to include screening for associated malignancies. Upper aerodigestive tract cancer often develops in patients with smoking-related lung cancer; however, little is known about the frequencies or types of other primary malignancies in patients with non-small cell lung cancer (NSCLC) without a history of smoking. We retrospectively evaluated the records of patients examined and/or treated for NSCLC at the Institute of Biomedical Research and Innovation between January 2007 and June 2012. Patients In total, 938 patients, including 599 men (never-smoker/ever-smoker: 35/564) and 339 women (never-smoker/ever-smoker: 236/103), were analyzed. Among the 209 patients (22.3%) with multiple primary malignancies, 151 had a history of smoking and 58 were never-smokers. The most common cancers were gastric (43 cases), colorectal (33 cases), and prostate (29 cases) cancer. Smoking-related cancer was more common in current smokers and ex-smokers for both men and women. Among women with NSCLC, never-smokers were more likely to have thyroid cancer than those with a history of...Continue Reading

References

Mar 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F E van LeeuwenR Somers
Feb 2, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A J SwerdlowD C Linch
Nov 4, 2000·Biochemical and Biophysical Research Communications·H OhuchiN Itoh
Apr 6, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L TeppoE Pukkala
Aug 15, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E RadzikowskaK Roszkowski
Mar 19, 2003·Lancet·Henrik Grönberg
May 19, 2004·International Journal of Urology : Official Journal of the Japanese Urological Association·Soshu SatoTomohiko Koyanagi
Nov 4, 2004·International Journal of Cancer. Journal International Du Cancer·Jay D HuntPaul Brennan
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Oct 19, 2005·International Journal of Cancer. Journal International Du Cancer·Hisayuki Shigematsu, Adi F Gazdar
Feb 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Janakiraman Subramanian, Ramaswamy Govindan
May 1, 2007·Surgery Today·Shuji HaraguchiKazuo Shimizu
Jun 5, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jacinthe FoegléElisabeth Quoix
Aug 29, 2007·Radiation Research·D L PrestonK Kodama
Oct 1, 2008·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Rafael AguilóAna Maria Novoa
Aug 12, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alice T ShawA John Iafrate
Nov 6, 2009·The Lancet Oncology·Béatrice SecretanUNKNOWN WHO International Agency for Research on Cancer Monograph Working Group
May 27, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Tomoya KawaguchiYosihito Maruyama
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayDonald Maxwell Parkin
Aug 19, 2011·JAMA : the Journal of the American Medical Association·Neal D FreedmanChristian C Abnet

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Citations

Feb 14, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·C L L Lopez-OlivaI Han
Nov 1, 2016·Scientific Reports·Yang YangGening Jiang
Sep 3, 2017·International Journal of Clinical Oncology·Takuma TsukiokaNoritoshi Nishiyama
Jun 30, 2018·International Journal of Environmental Research and Public Health·Xue NiQiang Wang
Nov 29, 2020·Cancer Treatment and Research Communications·Amit SingnurkarGregory R Pond

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