Multiple primary malignant neoplasms: A 10-year experience at a single institution from Turkey

Journal of Cancer Research and Therapeutics
Durmus EtizMelek Akcay

Abstract

The development of improved diagnostic techniques, increased survival, and life expectancy of cancer patients have all contributed to the higher frequency of multiple primary malignant neoplasms (MPMN). MPMN can be divided into two main categories: Synchronous MPMN (sMPMN) and metachronous MPMN (mMPMN). 122 patients with MPMN analyzed retrospectively who were admitted to the Radiation Oncology Department of Eskisehir Osmangazi University Medical Faculty from January 2004 to December 2013. The patient characteristics and relation with overall survival (OS) were examined. The overall incidence of MPMN was found 1.2% in our institution. The median age was 59 (range: 29-80) years. Male:female ratio was 54.5:45.5%, and mMPMN:sMPMN ratio was 69.9:30.1%. The most common 3 cancers were head and neck (22%), breast (20%), and gastrointestinal (20%) for first primary; and gastrointestinal (22%), lung (19%), gynecologic tumors (15%) for second primary cancers, respectively. The median OS in patients with sMPMN and mMPMN were 30 (3-105) and 91 (4-493) months. 2, 3, and 5 years OS of patients with sMPMN were 86%, 75%, 63%, and with mMPMN were 92%, 88%, 80%, respectively (P < 0.005). OS was found longer in female patients with sMPMN (P < 0.05...Continue Reading

References

Jun 16, 2011·The Journal of International Medical Research·B GurselE Odabas
Apr 1, 2014·Genetics and Molecular Research : GMR·L L Xu, K S Gu
Jan 27, 2016·Cancer Causes & Control : CCC·Hannah K WeirMichel P Coleman

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