Multiple quantitative trait locus analysis of bovine chromosome 6 in the Israeli Holstein population by a daughter design.

Genetics
M RonJ I Weller

Abstract

Nine Israeli Holstein sire families with 2978 daughters were analyzed for quantitative trait loci effects on chromosome 6 for five milk production traits by a daughter design. All animals were genotyped for 2 markers. The three families with significant effects were genotyped for up to 10 additional markers spanning positions 0-122 cM of BTA6. Two sires were segregating for a locus affecting protein and fat percentage near position 55 cM with an estimated substitution effect of 0.18% protein, which is equivalent to one phenotypic standard deviation. This locus was localized to a confidence interval of 4 cM. One of these sires was also heterozygous for a locus affecting milk, fat, and protein production near the centromere. The hypothesis of two segregating loci was verified by multiple regression analysis. A third sire was heterozygous for a locus affecting milk and protein percentage near the telomeric end of the chromosome. Possible candidates for the major quantitative gene near position 55 cM were determined by comparative mapping. IBSP and SSP1 were used as anchors for the orthologous region on human chromosome 4. Twelve genes were detected within a 2-Mbp sequence. None of these genes have been previously associated with l...Continue Reading

References

Nov 1, 1994·Genetics·G A Churchill, R W Doerge
Jun 1, 1996·Genetics·P M VisscherC S Haley
Jul 1, 1996·The Journal of Heredity·R Z MaH A Lewin
Jul 31, 1998·Journal of Dairy Science·C Israel, J I Weller
Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·J RiquetM Georges
Sep 14, 2000·Genome Research·M R BandH A Lewin
Feb 15, 2001·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J NadesalingamJ P Gibson
Feb 22, 2001·Science·J C VenterX Zhu
Jul 1, 1996·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·S A KnottC S Haley
Dec 1, 1992·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·O Martínez, R N Curnow

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Citations

Jul 1, 2008·Animal : an International Journal of Animal Bioscience·M S TantiaR K Vijh
May 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Robert D SchnabelJeremy F Taylor
Feb 5, 2008·Animal Genetics·B J HayesT H E Meuwissen
Jan 17, 2009·Journal of Genetics·Chengsong ZhuZhigang Guo
Mar 27, 2009·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·M ArnyasiA Jávor
Sep 21, 2004·Journal of Dairy Science·C SchrootenH Bovenhuis
Oct 19, 2005·Journal of Dairy Science·S LeonardC Maltecca
Apr 22, 2003·Journal of Dairy Science·G FreyerI Hoeschele
Dec 13, 2005·Genome Research·James E Womack
Jul 29, 2011·Animal Science Journal = Nihon Chikusan Gakkaihō·Amonrat MoleeNoppanan Rungsakinnin

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