PMID: 11902901Mar 21, 2002Paper

Multiple quantum filtered NMR studies of the interaction between collagen and water in the tendon

Journal of the American Chemical Society
Uzi Eliav, Gil Navon

Abstract

We studied the physical processes and the chemical reactions involved in magnetization transfer between water and large proteins, such as collagen, in bovine Achilles tendon. Since the NMR spectrum for such proteins is broadened by very large dipolar interactions, the NMR peaks of the various functional groups on the protein cannot be separated from one another on the basis of their different chemical shifts. A further complication in observing the protein spectrum is the intense narrow peak of the abundant water. Thus, magnetization transfer (MT) within the protein or between water and the protein cannot rely on differences in the chemical shifts, as is commonly possible in liquids. We present a method that separates the protein spectrum from that of the water spectrum on the basis of their different intramolecular dipolar interactions, enabling exclusive excitation of either the protein or water. As a result, the protein spectrum as well as the effect of spin diffusion within the protein can be measured. In addition, the MT rates from the protein to water and vice versa can be measured. Two types of mechanisms were considered for the MT: chemical exchange- and dipolar interaction-related processes (such as NOE). They were dis...Continue Reading

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Citations

Sep 25, 2012·Magma·Slawomir KusmiaGeneviève Guillot
Oct 22, 2003·Journal of Magnetic Resonance·R FecheteB Blümich
Feb 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Wen LingAlexej Jerschow
Apr 17, 2013·Journal of Magnetic Resonance·Uzi EliavGil Navon
Jul 19, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Henry H OngFelix W Wehrli
Apr 19, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Richard J HodgsonMatthew D Robson
Feb 16, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Uzi EliavGil Navon
Apr 3, 2015·Journal of Food Science·Franco BelliniIgnacio Rintoul
Jul 24, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Arnon NeufeldGil Navon
Jul 11, 2006·NMR in Biomedicine·Göran Zernia, Daniel Huster
Jan 30, 2007·Journal of Magnetic Resonance Imaging : JMRI·Gary D Fullerton, Andrés Rahal
Jan 30, 2007·Journal of Magnetic Resonance Imaging : JMRI·G NavonB Blümich
Apr 22, 2008·Journal of Magnetic Resonance Imaging : JMRI·Amir HarelGil Navon
Oct 12, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Dina CarassoGil Navon
Dec 2, 2005·NMR in Biomedicine·R FecheteG Navon
Jan 22, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Uzi EliavGil Navon
Sep 25, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yang ZhouNirbhay N Yadav
Mar 6, 2015·The Journal of Physical Chemistry. B·Michal RivlinGil Navon
Dec 22, 2017·The Journal of Physical Chemistry. B·Aafiya TarannumNishter Nishad Fathima
Dec 15, 2006·Journal of the American Chemical Society·Uzi Eliav, Gil Navon
Oct 27, 2006·The Journal of Physical Chemistry. B·Fabian Vaca ChavezBertil Halle

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