Multiple Ras signals pattern the Drosophila ovarian follicle cells

Developmental Biology
T Lee, D J Montell

Abstract

During Drosophila oogenesis, spatially restricted activity of the TORPEDO receptor tyrosine kinase first recruits follicle cells adjacent to the oocyte to a posterior cell fate and then specifies dorsal follicle cells. Another receptor tyrosine kinase, BREATHLESS, stimulates migration of the anterior follicle cells known as border cells. Since Ras is known to mediate many receptor tyrosine kinase effects, we have investigated the role of Ras in follicle cell fate determination, differentiation, and migration throughout oogenesis. Early ectopic Ras activity induced transient expression of posterior follicle cell markers in anterior follicle cells, but did not inhibit anterior differentiation. Later ectopic Ras activity inhibited anterior follicle cell differentiation but did not induce posterior marker expression. Complete transformation of anterior follicle cells to posterior follicle cells required early ectopic Ras activity in egg chambers where terminal differentiation of anterior cells was inhibited. These results suggest that, in vivo as in vitro, Ras can have diverse effects on different cells, but, in addition, Ras activity can have different effects on the same cells at different stages in their development.

References

Jun 1, 1993·Journal of Neurobiology·T Venkatesh

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Citations

Aug 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·John S Poulton, Wu-Min Deng
Mar 17, 2018·Nature Reviews. Cancer·Christina H StueltenDenise J Montell
Nov 6, 2018·G3 : Genes - Genomes - Genetics·Julia Wittes, Trudi Schüpbach
Apr 6, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Josefa Steinhauer, Daniel Kalderon
Apr 17, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jennifer F HackneyLeonard Dobens
May 24, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·L L Dobens, L A Raftery
Sep 22, 2007·Developmental Biology·John S Poulton, Wu-Min Deng

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