PMID: 9162115May 1, 1997Paper

Multiple recruitment of class-I aldolase to chloroplasts and eubacterial origin of eukaryotic class-II aldolases revealed by cDNAs from Euglena gracilis

Current Genetics
M PlaumannC Schnarrenberger

Abstract

The photosynthetic protist Euglena gracilis is one of few organisms known to possess both class-I and class-II fructose-1,6-bisphosphate aldolases (FBA). We have isolated cDNA clones encoding the precursor of chloroplast class-I FBA and cytosolic class-II FBA from Euglena. Chloroplast class-I FBA is encoded as a single subunit rather than as a polyprotein, its deduced transit peptide of 139 amino acids possesses structural motifs neccessary for precursor import across Euglena's three outer chloroplast membranes. Evolutionary analyses reveal that the class-I FBA of Euglena was recruited to the chloroplast independently from the chloroplast class-I FBA of chlorophytes and may derive from the cytosolic homologue of the secondary chlorophytic endosymbiont. Two distinct subfamilies of class-II FBA genes are shown to exist in eubacteria, which can be traced to an ancient gene duplication which occurred in the common ancestor of contemporary gram-positive and proteobacterial lineages. Subsequent duplications involving eubacterial class-II FBA genes resulted in functional specialization of the encoded products for substrates other than fructose-1,6-bisphosphate. Class-II FBA genes of Euglena and ascomycetes are shown to be of eubacteri...Continue Reading

Citations

Aug 26, 2006·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Zhangkui WangQixin Sun
Oct 14, 2004·European Journal of Biochemistry·Ulrich NowitzkiWilliam Martin
Aug 3, 2010·Biochemistry. Biokhimii︠a︡·O N RozovaY A Trotsenko
Jan 5, 2011·BMC Microbiology·Anish BavishiMadhusudan Choudhary
Jun 23, 2007·BMC Biology·Matthew B RogersPatrick J Keeling
Oct 18, 2000·Biochemical and Biophysical Research Communications·J InagakiY Yamamoto
Jul 19, 2011·Protein Expression and Purification·Geneviève LabbéJ Guy Guillemette
Mar 30, 2018·The Journal of Biological Chemistry·Benoit JacquesJurgen Sygusch
Oct 6, 2004·Journal of Molecular Evolution·Oliver Kilian, Peter G Kroth
Jun 2, 2001·The Journal of Biological Chemistry·B SiebersC H Verhees
Dec 26, 2001·Biochimica Et Biophysica Acta·G G van DoorenG I McFadden
Sep 8, 2018·Chemical Reviews·Allie Y ChenSeth M Cohen

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