Multiple recurrent chromosomal breakpoints in mantle cell lymphoma revealed by a combination of molecular cytogenetic techniques

Genes, Chromosomes & Cancer
Itziar SalaverriaElías Campo

Abstract

Mantle cell lymphoma (MCL) is genetically characterized by 11q13 translocations leading to the overexpression of CCND1, and additional secondary genomic alterations that may be important in the progression of this disease. We have analyzed 22 MCL cases and 10 MCL cell lines using multicolor fluorescence in situ hybridization (M-FISH), FISH, and comparative genomic hybridization (CGH). The 19 cases with abnormal karyotype showed the t(11;14)(q13;q32) translocation and, additionally, 89% of cases showed both numerical (n = 58) and structural (n = 77) aberrations. All but one MCL cell line showed t(11;14) and structural and numerical alterations in highly complex karyotypes. Besides 11 and 14, the most commonly rearranged chromosomes were 1, 8, and 10 in the tumors and 1, 8, and 9 in the cell lines. No recurrent translocations other than the t(11;14) were identified. However, we identified 17 recurrent breakpoints, the most frequent being 1p22 and 8p11, each observed in four cases and two cell lines. Interestingly, five tumors and four cell lines displayed a complex t(11;14), cryptic in one case and two cell lines, preferentially involving chromosome 8. In typical MCL, ATM gene deletions were significantly associated with a high n...Continue Reading

References

Apr 1, 1990·Cancer Genetics and Cytogenetics·T S McConnellG W Dewald
Jan 1, 1997·International Journal of Radiation Biology·R K SachsD J Brenner
Apr 29, 1998·Genes, Chromosomes & Cancer·O MonniS Knuutila
Feb 15, 2001·Cancer Genetics and Cytogenetics·A G Bosga-BouwerE van den Berg
Jan 17, 2002·Genes, Chromosomes & Cancer·Alicja M Gruszka-WestwoodDaniel Catovsky
Aug 3, 2002·Leukemia & Lymphoma·Wing Y AuDouglas E Horsman
Apr 15, 2003·The Hematology Journal : the Official Journal of the European Haematology Association·Norma C GutiérrezJesús F San Miguel
Sep 24, 2004·Cancer Genetics and Cytogenetics·Sonia MaravelakiVasantha Brito-Babapulle
Jun 22, 2006·British Journal of Haematology·Sophie GazzoEvelyne Callet-Bauchu
Jul 11, 2006·Genes, Chromosomes & Cancer·Asha BalakrishnanDoris Steinemann
Feb 14, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Itziar SalaverriaElias Campo

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Citations

Feb 28, 2013·World Journal of Gastrointestinal Oncology·Xavier SagaertRhonda K Yantiss
Aug 25, 2010·Advances in Anatomic Pathology·Michele Roullet, Adam Bagg
Oct 6, 2010·Leukemia & Lymphoma·Wei Xu, Jian-Yong Li
Feb 25, 2014·Expert Review of Hematology·Yu Wang, Shuangge Ma
Sep 29, 2011·Seminars in Cancer Biology·Cristina RoyoSílvia Beà
Dec 2, 2010·Blood·Sietse M AukemaPhilip M Kluin
Jan 20, 2012·Annals of Laboratory Medicine·Yoonmi SeokKyung-A Lee
Jun 21, 2017·Journal of Internal Medicine·R RosenquistQ Pan-Hammarström
Jun 15, 2021·Genes, Chromosomes & Cancer·Joanna C DallandLinda B Baughn

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