Abstract
Mantle cell lymphoma (MCL) is genetically characterized by 11q13 translocations leading to the overexpression of CCND1, and additional secondary genomic alterations that may be important in the progression of this disease. We have analyzed 22 MCL cases and 10 MCL cell lines using multicolor fluorescence in situ hybridization (M-FISH), FISH, and comparative genomic hybridization (CGH). The 19 cases with abnormal karyotype showed the t(11;14)(q13;q32) translocation and, additionally, 89% of cases showed both numerical (n = 58) and structural (n = 77) aberrations. All but one MCL cell line showed t(11;14) and structural and numerical alterations in highly complex karyotypes. Besides 11 and 14, the most commonly rearranged chromosomes were 1, 8, and 10 in the tumors and 1, 8, and 9 in the cell lines. No recurrent translocations other than the t(11;14) were identified. However, we identified 17 recurrent breakpoints, the most frequent being 1p22 and 8p11, each observed in four cases and two cell lines. Interestingly, five tumors and four cell lines displayed a complex t(11;14), cryptic in one case and two cell lines, preferentially involving chromosome 8. In typical MCL, ATM gene deletions were significantly associated with a high n...Continue Reading
References
Apr 1, 1990·Cancer Genetics and Cytogenetics·T S McConnellG W Dewald
Apr 1, 1995·Human Immunology
Jan 1, 1997·International Journal of Radiation Biology·R K SachsD J Brenner
Apr 29, 1998·Genes, Chromosomes & Cancer·O MonniS Knuutila
May 18, 1999·Cancer Genetics and Cytogenetics·B EspinetJ Sans-Sabrafen
Feb 19, 2000·Genes, Chromosomes & Cancer·M BentzH Döhner
Mar 17, 2000·Leukemia·D LensL J Coignet
Feb 15, 2001·Cancer Genetics and Cytogenetics·A G Bosga-BouwerE van den Berg
Nov 24, 2001·Blood·J A Martinez-ClimentJ García-Conde
Jan 5, 2002·Blood·Emma CamachoElias Campo
Jan 17, 2002·Genes, Chromosomes & Cancer·Alicja M Gruszka-WestwoodDaniel Catovsky
Feb 14, 2002·British Journal of Haematology·Jeannette E AllenDavid W Hammond
Jul 20, 2002·Leukemia Research·R LaiR J Ford
Aug 3, 2002·Leukemia & Lymphoma·Wing Y AuDouglas E Horsman
Apr 15, 2003·The Hematology Journal : the Official Journal of the European Haematology Association·Norma C GutiérrezJesús F San Miguel
May 14, 2003·Cancer Genetics and Cytogenetics·R M'kacherA Bernheim
Aug 22, 2003·British Journal of Haematology·Valia S LestouDouglas E Horsman
Apr 20, 2004·Blood·Holger KohlhammerMartin Bentz
Jun 30, 2004·Leukemia & Lymphoma·M JarosováK Indrák
Jul 22, 2004·Blood·Carsten HirtGottfried Dölken
Sep 24, 2004·Cancer Genetics and Cytogenetics·Sonia MaravelakiVasantha Brito-Babapulle
Oct 23, 2004·Blood·Margit SchradersPatricia J T A Groenen
Dec 21, 2004·Oncogene·Hiroyuki TagawaMasao Seto
Feb 19, 2005·Blood·Fanny Rubio-MoscardoJose A Martinez-Climent
Jan 18, 2006·British Journal of Haematology·Andrea RinaldiFrancesco Bertoni
Feb 2, 2006·Leukemia Research·Jordi CampsElías Campo
Jun 22, 2006·British Journal of Haematology·Sophie GazzoEvelyne Callet-Bauchu
Jul 11, 2006·Genes, Chromosomes & Cancer·Asha BalakrishnanDoris Steinemann
Feb 14, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Itziar SalaverriaElias Campo
Feb 15, 2007·Blood·Adrian WiestnerLouis M Staudt
Jul 17, 2007·Leukemia Research·Julia Slotta-HuspeninaFalko Fend
Sep 25, 2007·Nature Reviews. Cancer·Pedro JaresElias Campo
Nov 15, 2007·Cytogenetic and Genome Research·G NanjangudR S K Chaganti
Nov 21, 2007·Leukemia Research·Cristina BaróFrancesc Solé
Feb 16, 2008·British Journal of Haematology·Itziar SalaverriaElias Campo
Mar 28, 2008·Haematologica·Bibiana I FerreiraJuan C Cigudosa
May 3, 2008·Haematologica·Sílvia Beà, Elías Campo
Citations
May 29, 2009·Journal of Virology·Magdalena Julia DabrowskaFinn Skou Pedersen
Nov 6, 2008·Blood·Sílvia BeàElias Campo
Nov 3, 2009·Haematologica·Ana MozosElias Campo
Feb 9, 2012·Haematologica·Julia Slotta-HuspeninaLeticia Quintanilla-Martinez
Feb 28, 2013·World Journal of Gastrointestinal Oncology·Xavier SagaertRhonda K Yantiss
Apr 5, 2011·Molecular Cytogenetics·Cristiano Krings RochaKarl-Anton Kreuzer
Aug 25, 2010·Advances in Anatomic Pathology·Michele Roullet, Adam Bagg
Oct 6, 2010·Leukemia & Lymphoma·Wei Xu, Jian-Yong Li
Aug 20, 2011·Leukemia & Lymphoma·Martin DreylingUNKNOWN European Mantle Cell Lymphoma Network
Feb 25, 2014·Expert Review of Hematology·Yu Wang, Shuangge Ma
Sep 29, 2011·Seminars in Cancer Biology·Cristina RoyoSílvia Beà
Jul 26, 2011·Seminars in Hematology·Alba NavarroElías Campo
Sep 18, 2013·Acta Ophthalmologica·Peter Kristian Rasmussen
Feb 10, 2010·Genes, Chromosomes & Cancer·Blanca EspinetFrancesc Solé
Nov 10, 2012·Leukemia Research·Georgia SchillingJudith Dierlamm
Dec 2, 2010·Blood·Sietse M AukemaPhilip M Kluin
Jan 20, 2012·Annals of Laboratory Medicine·Yoonmi SeokKyung-A Lee
May 31, 2020·Hematological Oncology·Yannick Le BrisSteven Le Gouill
Jun 21, 2017·Journal of Internal Medicine·R RosenquistQ Pan-Hammarström
Jun 15, 2021·Genes, Chromosomes & Cancer·Joanna C DallandLinda B Baughn