Multiple regions within the coxsackievirus and adenovirus receptor cytoplasmic domain are required for basolateral sorting

The Journal of Biological Chemistry
C J CohenJeffrey M Bergelson

Abstract

The coxsackievirus and adenovirus receptor (CAR) mediates attachment and infection by coxsackie B viruses and many adenoviruses. In human airway epithelia, as well as in transfected Madin-Darby canine kidney cells, CAR is expressed exclusively on the basolateral surface. Variants of CAR that lack the cytoplasmic domain or are attached to the cell membrane by a glycosylphosphatidylinositol anchor are expressed on both the apical and basolateral surfaces. We have examined the localization of CAR variants with progressive truncations of the cytoplasmic domain, as well as with mutations that ablate a potential PDZ (PSD95/dlg/ZO-1) interaction motif and a putative tyrosine-based sorting signal. In addition, we have examined the targeting of two murine CAR isoforms, with different C-terminal sequences. The results suggest that multiple regions within the CAR cytoplasmic domain contain information that is necessary for basolateral targeting.

References

Feb 14, 1997·The Journal of Biological Chemistry·A H Le GallE Rodriguez-Boulan
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·R P TomkoL Philipson
Jan 7, 1998·Journal of Virology·J M BergelsonR W Finberg
Feb 18, 1999·The Journal of Clinical Investigation·R C Boucher
Mar 17, 1999·The Journal of Clinical Investigation·A S Fanning, J M Anderson
Nov 24, 1999·The Journal of Clinical Investigation·B D MoyerB A Stanton
May 18, 2000·Brain Research. Molecular Brain Research·T HondaR Kuwano

❮ Previous
Next ❯

Citations

Apr 2, 2003·Current Atherosclerosis Reports·Philip L Leopold
Sep 5, 2002·Biochemical and Biophysical Research Communications·Shinya SuzuKazuo Motoyoshi
Jul 4, 2002·Fertility and Sterility·John C M TsibrisWilliam N Spellacy
May 24, 2003·Brain Research. Developmental Brain Research·Yuko HottaRyozo Kuwano
Jun 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Fernando DiazEnrique Rodriguez-Boulan
Feb 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jose Maria Carvajal-GonzalezEnrique Rodriguez-Boulan
May 22, 2002·Journal of Virology·Wouter van't Hof, Ronald G Crystal
Jan 29, 2003·Journal of Virology·Katherine J D Ashbourne ExcoffonJoseph Zabner
Jul 16, 2004·Journal of Virology·Theresa VincentPhilip L Leopold
Mar 13, 2010·Journal of Biomedicine & Biotechnology·H BauerH C Bauer
Mar 22, 2005·American Journal of Respiratory Cell and Molecular Biology·Katherine J D A ExcoffonJoseph Zabner
Aug 19, 2011·PloS One·Fawziyah HussainGeorge Santis
Oct 29, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·R P HooleyP T K Saunders
Dec 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·C J CohenJ M Bergelson
Oct 12, 2012·Neurochemical Research·Hansjürgen VolkmerFritz G Rathjen
Jan 8, 2014·The Journal of Cell Biology·Juan S Bonifacino
Jun 17, 2009·Experimental Cell Research·Charlotte FarmerMaddy Parsons
Jun 8, 2012·Annals of the New York Academy of Sciences·Jörg-Dieter SchulzkeMichael Fromm
Jul 22, 2004·Experimental Cell Research·Ansgar Brüning, Ingo B Runnebaum
Apr 27, 2005·Brain Research. Brain Research Reviews·Mathieu HauwelPhilippe Gasque
May 12, 2007·Biochimie·Julie ClaudinonChristophe Lamaze
Jan 11, 2007·The Journal of Biological Chemistry·Patrick T FokJosephine Nalbantoglu
Feb 24, 2004·The Journal of Biological Chemistry·Andrea DörnerKirk U Knowlton
Feb 14, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Qing YuDon C Rockey
Jun 17, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Maki NagaiTadashi Yamamoto
Jun 8, 2017·Experimental and Therapeutic Medicine·Jingjin LiuShuo Zhang
May 19, 2017·Neurogenesis·Sara SalinasEric J Kremer
Sep 16, 2011·The Journal of General Virology·Priyanka SharmaKatherine Julie Diane Ashbourne Excoffon
Jan 31, 2021·International Journal of Molecular Sciences·Janik BöhnkeClaudia Claus
Aug 12, 2004·Journal of Cell Science·Katherine J D Ashbourne ExcoffonJoseph Zabner

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.