PMID: 11897851Mar 19, 2002Paper

Multiple regulation by external ATP of nifedipine-insensitive, high voltage-activated Ca(2+) current in guinea-pig mesenteric terminal arteriole

The Journal of Physiology
Hiromitsu MoritaRyuji Inoue

Abstract

We investigated the receptor-mediated regulation of nifedipine-insensitive, high voltage-activated Ca(2+) currents in guinea-pig terminal mesenteric arterioles (I(mVDCC)) using the whole-cell clamp technique. Screening of various vasoactive substances revealed that ATP, histamine and substance P exert modulatory effects on I(mVDCC). The effects of ATP on I(mVDCC) after complete P2X receptor desensitization exhibited a complex concentration dependence. With 5 mM Ba(2+), ATP potentiated I(mVDCC) at low concentrations (approximately 1-100 microM), but inhibited it at higher concentrations (>100 microM). The potentiating effects of ATP were abolished by suramin (100 microM) and PPADS (10 microM) and by intracellular application of GDPbetaS (500 microM), whereas a substantial part of I(mVDCC) inhibition by milimolar concentrations of ATP remained unaffected; due probably to its divalent cation chelating actions. In divalent cation-free solution, I(mVDCC) was enlarged and underwent biphasic effects by ATPgammaS and ADP, while 2-methylthio ATP (2MeSATP) exerted only inhibition, and pyrimidines such as UTP and UDP were ineffective. ATP-induced I(mVDCC) potentiation was selectively inhibited by anti-Galpha(s) antibodies or protein kinas...Continue Reading

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Citations

Feb 15, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Laszlo KölesPeter Illes
Apr 30, 2008·Purinergic Signalling·Manuela MoratoAntónio Albino-Teixeira
Sep 2, 2008·Clinical and Experimental Pharmacology & Physiology·Manuel F Navarro-GonzalezCaryl E Hill
Feb 1, 2014·Pflügers Archiv : European journal of physiology·Ivana Y-T KuoCaryl E Hill
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Alberto Del Valle-RodríguezJuan Ureña
Feb 26, 2011·Journal of Pharmacological Sciences·Megumi SugiharaMasato Hirata
Aug 3, 2004·Journal of Pharmacological Sciences·Toyohisa HananoRyuji Inoue
Dec 18, 2013·Pharmacological Reviews·Geoffrey Burnstock, Vera Ralevic
Jul 1, 2020·Cellular and Molecular Life Sciences : CMLS·Madeline Nieves-CintrónManuel F Navedo
Oct 21, 2021·Cardiovascular Research·Benjamin GrimmerWolfgang M Kuebler

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