Multiple-Responsive Mesoporous Silica Nanoparticles for Highly Accurate Drugs Delivery to Tumor Cells

ACS Omega
Ronghua JinXin Chen

Abstract

A core-shell nanocarrier with triple layers, where each layer is sensitive to one specific physiological stimulus, has been fabricated for highly accurate cancer therapy. The nanocarrier consists of mesoporous silica nanoparticles (core structure for drug loading), fluorescein isothiocyanate-labeled hyaluronan (FITC-HA, first shell for imaging with enzymatic response), disulfide bond-embedded silica (SiO2, second layer with glutathione response), and switchable zwitterionic surface (third layer with pH response). The nanocarrier decorated with zwitterionic surface is able to offer long blood circulation time due to the weak nonspecific protein absorption. After these nanocarriers were gradually gathered around tumor cells through enhanced permeability and retention effect, the zwitterionic surface could switch to positive charge in low-pH environment, which was in favor of cellular uptake due to the strengthened positive nanocarrier-negative cellular membrane interaction. Once internalized into tumor cells, the high concentration of glutathione in cytoplasm could cleave disulfide bonds to remove the SiO2 shell and the HA layer would be exposed, which would be further degraded by hyaluronidase to trigger payload release. The flu...Continue Reading

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Citations

Aug 8, 2019·Journal of Biomedical Materials Research. Part a·Md AquibBo Wang
Aug 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cristina ChircovȘtefan Claudiu Turculeƫ
Mar 1, 2019·International Journal of Molecular Sciences·Safia NazJinghua Chen
Aug 18, 2020·Computational and Structural Biotechnology Journal·Ling-Yan ZhouZhi-Yao He
Apr 19, 2019·Colloids and Surfaces. B, Biointerfaces·Brittany E GivensJennifer Fiegel
May 6, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Rajesh SalveWassana Yantasee
Nov 15, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Ali PourjavadiMehdi Akhlaghi

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Methods Mentioned

BETA
transmission electron microscopy
dynamic light-scattering
Fluorescence
dynamic light scattering
fluorescence spectroscopy

Software Mentioned

Delsa Nano

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