Multiple resting state network functional connectivity abnormalities in mild traumatic brain injury

Brain Imaging and Behavior
Michael C StevensSuzanne T Witt

Abstract

Several reports show that traumatic brain injury (TBI) results in abnormalities in the coordinated activation among brain regions. Because most previous studies examined moderate/severe TBI, the extensiveness of functional connectivity abnormalities and their relationship to postconcussive complaints or white matter microstructural damage are unclear in mild TBI. This study characterized widespread injury effects on multiple integrated neural networks typically observed during a task-unconstrained "resting state" in mild TBI patients. Whole brain functional connectivity for twelve separate networks was identified using independent component analysis (ICA) of fMRI data collected from thirty mild TBI patients mostly free of macroscopic intracerebral injury and thirty demographically-matched healthy control participants. Voxelwise group comparisons found abnormal mild TBI functional connectivity in every brain network identified by ICA, including visual processing, motor, limbic, and numerous circuits believed to underlie executive cognition. Abnormalities not only included functional connectivity deficits, but also enhancements possibly reflecting compensatory neural processes. Postconcussive symptom severity was linked to abnorm...Continue Reading

References

Jul 1, 1989·Injury·I M LowdonJ Cockin
Jun 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·D T StussM T Richard
Oct 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·H S LevinJ Ewert
Dec 1, 1988·The Journal of Trauma·J F Kraus, P Nourjah
May 1, 1988·Neurosurgery·H HugenholtzM T Richard
Apr 1, 1987·Journal of Neurology, Neurosurgery, and Psychiatry·T M McMillan, E E Glucksman
Feb 1, 1987·Journal of Neurosurgery·H S LevinR F Frankowski
Aug 1, 1984·Annals of Neurology·S E GandyM D Deck
Jun 1, 1981·Journal of Neurosurgical Nursing·R W Rimel
Sep 1, 1981·Neurosurgery·R W RimelJ A Jane
Nov 1, 1995·Neural Computation·A J Bell, T J Sejnowski
Sep 1, 1993·Brain Injury : [BI]·S C SteinS E Ross
Jan 1, 1996·Brain Injury : [BI]·D M SosinD J Thurman
Jun 1, 1997·Journal of Clinical and Experimental Neuropsychology·L M BinderG J Larrabee
Jun 1, 1997·Journal of Clinical and Experimental Neuropsychology·L M Binder
Dec 17, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·S Fleminger
Dec 17, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·S DebC Koutzoukis
Apr 17, 1999·Archives of Physical Medicine and Rehabilitation·C F RuffoloP H Lindsay
Mar 29, 2001·The Journal of Head Trauma Rehabilitation·E D Bigler
Mar 23, 2002·Journal of Clinical and Experimental Neuropsychology·S DikmenN Temkin
Apr 13, 2002·Neurosurgery·Michael McCreaLisa Berger
Jun 20, 2002·IEEE Transactions on Medical Imaging·L FreireJ F Mangin
Nov 27, 2002·Progress in Neurobiology·Karl Friston
Dec 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Michael D GreiciusVinod Menon
Jun 25, 2003·Journal of Neurotrauma·Nancy R TemkinSureyya S Dikmen
Oct 24, 2003·AJR. American Journal of Roentgenology·Thomas PtakRobert A Novelline
Jan 1, 1992·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·W D GouvierQ Cutlip
Nov 1, 2003·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Stefanie L GriffinJames G Scott
Jan 28, 2004·Biological Psychiatry·Roma A VasaJoan P Gerring
Mar 26, 2004·Cognitive, Affective & Behavioral Neuroscience·Tor D Wager, Edward E Smith
Jul 28, 2004·International Review of Psychiatry·David J Schretlen, Anne M Shapiro
Apr 27, 2005·Cognitive, Affective & Behavioral Neuroscience·Adam GazzaleyMark D'Esposito
May 24, 2005·NeuroImage·Derek K JonesRobert J Howard
Jun 15, 2005·Archives of Physical Medicine and Rehabilitation·David K RyserErin D Bigler
Jun 23, 2005·Journal of Clinical and Experimental Neuropsychology·Katherine A R FrenchamMurray T Maybery

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Citations

Aug 27, 2013·Neuropsychology Review·Erin D Bigler
May 3, 2012·Brain Imaging and Behavior·Sara B Rosenbaum, Michael L Lipton
May 24, 2012·Brain Imaging and Behavior·Brenna C McDonaldThomas W McAllister
Jan 31, 2013·Seminars in Neurology·Brian L Edlow, Ona Wu
Jan 9, 2013·Brain Connectivity·Chandan J Vaidya, Evan M Gordon
Jul 23, 2013·Brain : a Journal of Neurology·Robert Leech, David J Sharp
Nov 13, 2013·Annual Review of Psychology·Amanda R RabinowitzHarvey S Levin
Feb 12, 2014·Nature Reviews. Neurology·David J SharpRobert Leech
Jul 18, 2014·Alzheimer's Research & Therapy·Thomas Sc NgMartha E Shenton
May 2, 2014·Journal of Neurotrauma·Andrew B DoddAndrew R Mayer
Jun 6, 2014·Journal of Neurotrauma·Katia J SinopoliMichelle Keightley
Feb 18, 2016·Scientific Reports·Love Engström NordinTie-Qiang Li
May 29, 2015·International Journal of Molecular Sciences·Cesar ReisJohn H Zhang
Feb 24, 2016·Annals of Clinical and Translational Neurology·Elizabeth W PangMargot J Taylor
Feb 28, 2015·Brain and Behavior·Philip Ja DeanAnnette Sterr
May 13, 2015·Journal of Neurotrauma·Harm J van der HornJoukje van der Naalt
Feb 26, 2016·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Marios AntonakakisAndrew C Papanicolaou
Mar 30, 2016·Current Neurology and Neuroscience Reports·Yousef Hannawi, Robert D Stevens
Sep 9, 2015·The Journal of Nervous and Mental Disease·Jie ZhanHonghan Gong
Apr 7, 2016·European Radiology·Jian LiHonghan Gong
Apr 16, 2013·NeuroImage·Kuang-Chi TungHanzhang Lu
Oct 16, 2014·Journal of Neurotrauma·Andrew MayerFaith M Hanlon
Dec 2, 2014·Neuroscience and Biobehavioral Reviews·Andrew R MayerFaith M Hanlon
May 8, 2016·Physical Medicine and Rehabilitation Clinics of North America·Justin M HonceLidia Nagae
Jun 4, 2016·Brain : a Journal of Neurology·Peter O JenkinsDavid J Sharp
May 31, 2016·Social Neuroscience·Stefon van NoordtDawn Good
Sep 19, 2014·Neurosurgery·Esther L YuhGeoffrey T Manley
Jan 28, 2017·PloS One·Harm J van der HornJoukje van der Naalt

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