Multiple risk factors and ischaemic stroke in the elderly Asian population with and without atrial fibrillation. An analysis of 425,600 Chinese individuals without prior stroke

Thrombosis and Haemostasis
Yutao GuoGregory Y H Lip

Abstract

Ischaemic stroke risk rises with the increasing cardiovascular risk factors. How atrial fibrillation (AF) incrementally contributes to the risk for ischaemic stroke with increasing age and multiple cardiovascular risk factors is unclear. In an individual patient with AF the mechanism of ischaemic stroke may be related directly to AF itself or to risk factors associated with AF. It was this study's objective to investigate incident ischaemic stroke in relation to age and increasing cardiovascular risk factor(s), and the incremental impact of AF on stroke rates. We studied a 5% random sampling from Chinese medical insurance data covering more than 10 million individuals, for the years 2001 to 2012. The rate of ischaemic stroke was calculated amongst the individuals with no prior history of ischaemic stroke, in relation to age groups (aged < 65, 65-74, ≥ 75 years old; n = 348,431, n = 56,952, n = 20,217, respectively), and increasing risk factors using the CHA2DS2-VASc score. Among the randomly sampled 425,600 individuals with total follow-up of 1,864,232 patient-years [63.8% male, mean age 60 years; 880 with AF, vs 424,720 non-AF], there were 13,242 (3.1%) ischaemic strokes after 64,834 person-years follow-up. Overall, ischaemic ...Continue Reading

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Citations

Aug 18, 2016·European Heart Journal. Cardiovascular Pharmacotherapy·Farhan ShahidGregory Y H Lip
Mar 13, 2018·Current Opinion in Psychiatry·Mary V Seeman, Alexandre González-Rodríguez
Apr 24, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A A Khan, G Y H Lip
Feb 6, 2019·European Journal of Clinical Pharmacology·Alenka Premuš Marušič KovačičDanijel Petrovič
Jun 12, 2018·Journal of Stroke·Wenhong DongUNKNOWN China Kadoorie Biobank Collaborative Group
Oct 7, 2017·American Journal of Hypertension·María Asunción Esteve-PastorGregory Y H Lip
Jul 1, 2017·Thrombosis and Haemostasis·Gregory Y H LipTatjana S Potpara

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