Multiple risks analysis for aplastic anemia in Zhejiang, China: A case-control study

Medicine
Li-Qiang WuSheng-Yun Lin

Abstract

To understand the risks associated with aplastic anemia (AA) in 4 cities of Zhejiang Province, China, with special focus on the joint contributions of multiple risks.Based on an Electronic Data Capture (EDC), a case control study was carried out. Data regarding socio-demographic, diseases history, living habits, and exposures to toxic substances, etc., were collected through survey questionnaires. t Test, chi-square test, or non-parametric rank sum test, and univariate and multivariate Logistic regression analysis were conducted to analyze data.The univariate logistic regression analysis results indicated that among all study participants (n = 1802), AA was associated with over 30 risks, in terms of their individual behaviors, daily and environmental exposures, diseases history, and family history. Multivariate logistic regression analysis further confirmed that the independent risks related to AA included presence of chemical factory within 3 km of living residence (odds ratio [OR] = 8.73, 95% CI: 1.42-53.74, P = .019), living in a newly decorated house/apartment (OR = 25.37, 95% CI: 4.44-144.81, P < .001), vegetarian diet (OR = 131.60, 95% CI: 3.45-5020.16, P = .009), preference of sugar (OR = 89.38, 95% CI: 7.22-1106.44, P <...Continue Reading

References

Jan 23, 1998·American Journal of Industrial Medicine·X XuD C Christiani
Jul 14, 2005·Clinical Medicine & Research·Jichun Chen
Jun 17, 2006·Blood·Neal S YoungPhillip Scheinberg
Apr 19, 2011·Expert Review of Hematology·Amy E Dezern, Robert A Brodsky
Nov 21, 2012·Bone Marrow Transplantation·C DufourUNKNOWN Severe Aplastic Anemia–Working Party of the EBMT
Nov 17, 2015·British Journal of Haematology·Sally B KillickUNKNOWN British Society for Standards in Haematology

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