PMID: 9620689Jun 10, 1998Paper

Multiple roles for hepatocyte growth factor in sympathetic neuron development

Neuron
F MainaA M Davies

Abstract

We have studied the role of hepatocyte growth factor (HGF)/Met signaling in the development of sympathetic neuroblasts and neurons. Anti-HGF antibodies reduced the number of sympathetic neuroblasts that differentiated into neurons, but neither anti-HGF antibodies nor HGF affected neuroblast proliferation. Anti-HGF antibodies also reduced the survival of neuroblasts but not sympathetic neurons. HGF greatly enhanced the neurite outgrowth of NGF-dependent sympathetic neurons throughout development. These in vitro effects of anti-HGF antibodies and HGF were abolished by a disabling mutation of Met, the HGF receptor tyrosine kinase. The Met mutation also increased sympathetic neuroblast apoptosis in vivo. Because Met and HGF are expressed in sympathetic ganglia throughout development, it is possible that the multiple effects of HGF/Met signaling on sympathetic neuroblasts and neurons occur in part by an autocrine mechanism.

References

Jun 1, 1990·The Journal of Cell Biology·E DiCicco-BloomI B Black
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·E DiCicco-Bloom, I B Black
Sep 4, 1987·Science·R Levi-Montalcini
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·T P RothmanD J Reis
Mar 1, 1996·Journal of Neuroscience Research·M HamanoueS Kohsaka
Feb 1, 1997·Current Opinion in Neurobiology·A M Davies
Nov 22, 1997·Current Biology : CB·M HiltonA M Davies
Feb 1, 1946·The Anatomical Record·M ABERCROMBIE

❮ Previous
Next ❯

Citations

Sep 5, 2002·Journal of Neuroscience Research·Henglin Yan, Scott A Rivkees
Dec 17, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hiroshi Funakoshi, Toshikazu Nakamura
Oct 6, 1999·Current Opinion in Neurobiology·A Chisholm, M Tessier-Lavigne
Oct 28, 1998·Trends in Cell Biology·C Birchmeier, E Gherardi
Mar 18, 2011·Cell Death & Disease·M GenestineR Dono
Apr 24, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Senda Ajroud-DrissJohn A Kessler
Jan 8, 2008·Nature Neuroscience·Gerard W O'KeeffeAlun M Davies
Nov 26, 2010·Nature Reviews. Molecular Cell Biology·Livio TrusolinoPaolo M Comoglio
Feb 28, 2002·The European Journal of Neuroscience·Oliver SchmidtAlun M Davies
May 22, 2001·Molecular Biology of the Cell·M C StellaP M Comoglio
Aug 27, 2005·Molecular Biology of the Cell·Maxine ChenBonnie L Firestein
Jul 11, 2006·Current Opinion in Pulmonary Medicine·Steven E MutsaersY C Gary Lee
Apr 15, 1999·Annual Review of Neuroscience·N J Francis, S C Landis
Apr 15, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shenfeng QiuGordon M G Shepherd
May 9, 2001·Biochemical and Biophysical Research Communications·H Funakoshi, T Nakamura
Jul 19, 2005·Annual Review of Neuroscience·Natalia O Glebova, David D Ginty
May 2, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hannes E BülowOliver Hobert
Sep 1, 2014·Cell and Tissue Research·Abbas HajifathaliMahsa Rasekhi
Dec 7, 2006·Developmental Neuroscience·Gabriela J MartinsElizabeth M Powell
Jun 29, 2012·Bioorganic & Medicinal Chemistry Letters·Francesco ColomboDaniele Passarella
Mar 27, 2012·Trends in Cell Biology·Maria AscanoRejji Kuruvilla
May 21, 2010·Neuropeptides·Masayuki KanehisaJotaro Akiyoshi
Sep 16, 2003·Journal of Neurobiology·Wohaib HasanPeter G Smith
Apr 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anice MoumenFlavio Maina
Sep 8, 2011·The European Journal of Neuroscience·Charles Finsterwald, Jean-Luc Martin
Oct 29, 2003·Neurological Research·J KoyamaT Moriizumi
Sep 3, 2013·Biochimica Et Biophysica Acta·María ArechederraAlmudena Porras

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
K Jin KimJohn Laterra
Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
I CañadasE Arriola
Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Keisei TachibanaMasayuki Noguchi
© 2021 Meta ULC. All rights reserved