Multiple roles of Sonic Hedgehog in the developing human cortex are suggested by its widespread distribution

Brain Structure & Function
Fani MemiNevena V Radonjić

Abstract

Sonic Hedgehog (Shh) plays an instrumental role in brain development, fine-tuning processes such as cell proliferation, patterning, and fate specification. Although, mutations in the SHH pathway in humans are associated with various neurodevelopmental disorders, ranging from holoprosencephaly to schizophrenia, its expression pattern in the developing human brain is not well established. We now determined the previously not reported wide expression of SHH in the human fetal cerebral cortex during most of the gestation period (10-40 gestational weeks). This spatiotemporal distribution puts Shh in a position to influence the fundamental processes involved in corticogenesis. SHH expression increased during development, shifting from progenitor cells in the proliferative zones to neurons, both glutamatergic and GABAergic, and astrocytes in upper cortical compartments. Importantly, the expression of its downstream effectors and complementary receptors revealed evolutionary differences in SHH-pathway gene expression between humans and rodents.

References

May 30, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·F M Benes, S Berretta
Dec 4, 2001·Genes & Development·P W Ingham, A P McMahon
Mar 5, 2005·Nature Neuroscience·Dimitris BourikasEsther T Stoeckli
Apr 2, 2005·Nature Reviews. Neuroscience·David A LewisDavid W Volk
May 3, 2005·Psychopharmacology·Alessandro GuidottiErminio Costa
Jun 6, 2006·American Journal of Medical Genetics. Part a·Giselda SantiagoAntonio Richieri-Costa
Sep 22, 2006·Nature Reviews. Neuroscience·Marc FuccilloGord Fishell
Jan 2, 2007·Current Biology : CB·Virginie ClementAriel Ruiz i Altaba
May 17, 2007·Genes & Development·David C Martinelli, Chen-Ming Fan
May 26, 2007·The Journal of Clinical Investigation·Maisa SeppalaMartyn T Cobourne
Jul 11, 2008·Development·Munekazu KomadaMakoto Ishibashi
Jun 29, 2010·American Journal of Medical Genetics. Part a·Lucilene Arilho RibeiroAntonio Richieri-Costa
Oct 29, 2010·Journal of Anatomy·Gavin ClowryPasko Rakic
Nov 12, 2010·Nature·Cagla Eroglu, Ben A Barres
Jan 11, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sabrina MalikPraveen Ballabh
Nov 5, 2013·Neuron·Daniel H Geschwind, Pasko Rakic
Jan 1, 2014·Frontiers in Cellular Neuroscience·J Alberto OrtegaNada Zecevic
Apr 4, 2014·Nature·Jeremy A MillerEd S Lein
Aug 26, 2014·Cerebral Cortex·Nevena V RadonjićNada Zecevic

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