Multiple roles of STAT3 in cardiovascular inflammatory responses

Progress in Molecular Biology and Translational Science
Cheh Peng Lim, Xin-Yuan Fu

Abstract

Cardiovascular inflammation has been regarded as a major cause for heart failure. However, the mechanisms that are involved in the regulation of cardiovascular inflammation are not well understood. In this chapter, we review the recent progress in revealing the roles of STAT3 in cardiovascular inflammation. Particularly, we discuss cardiomyocyte-specific STAT3-deficient mice and their phenotypes. An emerging view is that STAT3 plays a key role not only in cardiac protection but also in the control of cardiac-related inflammation.

Citations

Jul 28, 2012·Expert Opinion on Therapeutic Targets·Andrew S GiraudLouise M Judd
Jan 30, 2020·Cancer Immunology Research·Ashleigh R PohMatthias Ernst

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Robert H OakleyJohn A Cidlowski
JAK-STAT
Richard A KnightAnastasis Stephanou
© 2022 Meta ULC. All rights reserved