Multiple roles of the eyes absent gene in Drosophila

Developmental Biology
N M BoniniS Benzer

Abstract

The eyes absent (eya) gene plays an essential role in the events that lead to formation of the Drosophila eye; without expression of eya in retinal progenitor cells, they undergo programmed cell death just prior to the morphogenetic furrow, leading to an eyeless or reduced eye phenotype. The eya gene has recently been found to be highly conserved to humans, defining a new gene family. Insights into the gene's function in the fly, therefore, are likely to be relevant to the role of its homologs in vertebrates. Detailed studies at the subcellular level indicate that the Eya protein is localized to the nucleoplasm, suggesting a role in control of nuclear events. The eya gene shows expression and roles in tissues other than the eye, including subsets of cells of the adult visual system, brain, and ovary, as well as an elaborate expression pattern in the embryo. Various mutations in the eya gene cause loss of ocelli, female sterility, or lethality. Analysis of the embryonic lethal phenotype indicates that mutant alleles show defects in head morphogenesis. These data indicate that eya has critical roles in morphogenesis of a number of tissues in the animal, in addition to its role in early eye formation. Despite multiple roles at mul...Continue Reading

References

Oct 15, 1976·Developmental Biology·D F ReadyS Benzer
Apr 3, 1992·Cell·G I EvanD C Hancock
Dec 1, 1989·Developmental Biology·R L Cagan, D F Ready
Jan 1, 1970·Zeitschrift für Zellforschung und mikroskopische Anatomie·C C Dapples, R C King
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·L Y Jan, Y N Jan
Aug 1, 1995·Current Opinion in Genetics & Development·N M Bonini, K W Choi
Dec 1, 1994·Genetics·W M LeisersonS Benzer
Oct 21, 1994·Cell·Z N Oltvai, S J Korsmeyer
Jan 1, 1994·Annual Review of Neuroscience·S L Zipursky, G M Rubin
Oct 1, 1995·Current Opinion in Genetics & Development·G HalderW J Gehring
Jul 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·M K DuncanS I Tomarev
Nov 1, 1994·Trends in Cell Biology·B J Thomas, S L Zipursky
Jan 1, 1997·Cell Death and Differentiation·N M Bonini
Sep 1, 1984·Wilhelm Roux's Archives of Developmental Biology·C Nüsslein-VolhardH Kluding

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Citations

Sep 25, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J E Treisman
Oct 31, 2001·Development Genes and Evolution·J P Kumar, K Moses
Aug 31, 2011·Molecular Genetics and Genomics : MGG·Mark Charlton-PerkinsTiffany A Cook
Jul 19, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Pin-Xian Xu
Jun 5, 2003·Developmental Biology·James J FabrizioStephen DiNardo
Dec 24, 2008·BMC Developmental Biology·Torben SökerJochen Graw
Feb 15, 2007·PLoS Biology·Magnus BaumgardtStefan Thor
May 4, 2012·International Journal of Biological Sciences·Po-An YehChing-Jin Chang
Nov 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·W Patrick DevineMark A Krasnow
Jul 25, 2014·PloS One·Umesh C KarandikarGraeme Mardon
Sep 14, 2012·Cellular and Molecular Life Sciences : CMLS·Emmanuel Tadjuidje, Rashmi S Hegde
Mar 11, 2009·Journal of Molecular and Cellular Cardiology·Seung Hee LeeWoo Jin Park
Nov 14, 2006·Developmental Biology·Raphaelle GrifonePascal Maire
Dec 16, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·V KalatzisC Petit
Mar 29, 2018·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Yongjie FengMingyong Wang
Dec 17, 2015·Molecular and Cellular Biology·Ilaria Rebay
May 5, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Martin KriebelThomas Hollemann
Dec 17, 2003·Journal of Neurochemistry·John E ZimmermanAllan I Pack
Jul 9, 2005·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Gerhard Schlosser
Nov 20, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Karen M NeilsonSally A Moody
Mar 14, 2000·Cell Death and Differentiation·R A LockshinZ Zakeri
Feb 16, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Stephen BrownJames E Castelli-Gair Hombría
Jan 13, 2018·PLoS Genetics·Carolyn A MorrisonJessica E Treisman
Dec 16, 1998·The Journal of Cell Biology·M K PerezR N Pittman
Nov 9, 2001·The Journal of Biological Chemistry·S Wesley ClarkJohn L Cleveland
Jan 11, 2019·International Journal of Oncology·Bishnu Devi MaharjanTetsuya Nosaka
Jul 31, 2020·Critical Reviews in Biochemistry and Molecular Biology·Rashmi S HegdeRam Naresh Pandey
Jul 29, 2009·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Ying Dong, Markus Friedrich
Aug 8, 2015·The Indian Journal of Surgery·Peng RenCheng-Jun Zhou

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