Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system

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Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system

Abstract

Associated Clinical Trials

Comparison Between Clinical and MRI Multiple Sclerosis Activity and Expression of Human Endogenous Retrovirus Type W and Herpesvirus

References

Gelatinase in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological disorders.

Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen

A polyalanine peptide with only five native myelin basic protein residues induces autoimmune encephalomyelitis

Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin

Anti-tumor necrosis factor therapy abrogates autoimmune demyelination

Association between tumor necrosis factor-alpha and disease progression in patients with multiple sclerosis

What is the basis for HLA-DQ associations with autoimmune disease?

Adhesion molecules on endothelial cells in the central nervous system: an emerging area in the neuroimmunology of multiple sclerosis

Amino acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunity

Treatment of multiple sclerosis with gamma interferon: exacerbations associated with activation of the immune system

A population-based study of multiple sclerosis in twins

Fine specificity of the antibody response to myelin basic protein in the central nervous system in multiple sclerosis: the minimal B-cell epitope and a model of its features

The human myelin basic protein gene is included within a 179-kilobase transcription unit: expression in the immune and central nervous systems

Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon gamma and tumor necrosis factor alpha production

Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein

Multiple sclerosis. Presenting an odd autoantigen

Primary biliary cirrhosis: the molecule and the mimic

A genetic basis for familial aggregation in multiple sclerosis. Canadian Collaborative Study Group

Selection for T-cell receptor V beta-D beta-J beta gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis.

Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superantigen

Identification of an embryonic isoform of myelin basic protein that is expressed widely in the mouse embryo

Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases

Infection and multiple sclerosis: a possible role for superantigens?

Autoimmune thyroid disease

Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial. UBC MS/MRI Study Group and the IFNB Multiple Sclerosis Study Group

Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein

Apoptosis in brain-specific autoimmune disease

Major T-cell responses in multiple sclerosis

Citations

Susceptibility of human herpesvirus 6 to antiviral compounds by flow cytometry analysis

Myelin basic protein-specific and TCR V beta 8.2-specific T-cell lines from TCR V beta 8.2 transgenic mice utilize the same V alpha and V beta genes: specificity associated with the V alpha CDR3-J alpha region

Similar pattern of MCP-1 expression in spinal cords and eyes of Lewis rats with experimental autoimmune encephalomyelitis associated anterior uveitis

Digitized image analysis reveals diffuse abnormalities in normal-appearing white matter during acute experimental autoimmune encephalomyelitis

Increased reactivity to myelin oligodendrocyte glycoprotein peptides and epitope mapping in HLA DR2(15)+ multiple sclerosis

Lack of Th2 cytokine increase during spontaneous remission of experimental allergic encephalomyelitis

Severity of symptoms and demyelination in MOG-induced EAE depends on TNFR1

Self glycolipids as T-cell autoantigens

Transient virus infection and multiple sclerosis

Isolation of myelin basic protein-specific T cells predominantly from the memory T-cell compartment in multiple sclerosis

Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination

Patients with active relapsing-remitting multiple sclerosis synthesize antibodies recognizing oligodendrocyte progenitor cell surface protein: implications for remyelination

NBI-5788, an altered MBP83-99 peptide, induces a T-helper 2-like immune response in multiple sclerosis patients

The specificity of the antibody response in multiple sclerosis

Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors

Production of a recombinant hybrid molecule of cholera toxin-B-subunit and proteolipid-protein-peptide for the treatment of experimental encephalomyelitis

Specificity, magnitude, and kinetics of MOG-specific CD8+ T cell responses during experimental autoimmune encephalomyelitis

Axonal degeneration is an early pathological feature in autoimmune-mediated demyelination in mice

Tyrosine phosphorylation of p190 RhoGAP by Fyn regulates oligodendrocyte differentiation

Isolation of CD45RO+, memory T cells recognizing proteolipid protein from neurologically normal subjects

Antigen presentation in autoimmunity and CNS inflammation: how T lymphocytes recognize the brain

alpha4-Integrin antagonism with natalizumab: effects and adverse effects.

NMR structural elucidation of myelin basic protein epitope 83-99 implicated in multiple sclerosis

Conformational studies of immunodominant myelin basic protein 1-11 analogues using NMR and molecular modeling.

Mast cells and the adaptive immune response

Modulation of cannabinoid receptor activation as a neuroprotective strategy for EAE and stroke.

CNS infiltration of peripheral immune cells: D-Day for neurodegenerative disease?

New immunopathologic insights into multiple sclerosis

Traditional Chinese medicine and immune regulation.

Spatiotemporal patterns of dexamethasone-induced Ras protein 1 expression in the central nervous system of rats with experimental autoimmune encephalomyelitis.

Astrocyte, the star avatar: redefined.

Variants in the promoter region of CYP7A1 are associated with neuromyelitis optica but not with multiple sclerosis in the Han Chinese population

Neurological S1P signaling as an emerging mechanism of action of oral FTY720 (fingolimod) in multiple sclerosis

Maintenance and loss of self-tolerance in B cells

Genomic and proteomic analysis of multiple sclerosis. Opinion

Efficient purification of unique antibodies using peptide affinity-matrix columns

Crystal structure of the catalytic domain of human matrix metalloproteinase 10

CD134 plays a crucial role in the pathogenesis of EAE and is upregulated in the CNS of patients with multiple sclerosis

Alpha-lipoic acid is effective in prevention and treatment of experimental autoimmune encephalomyelitis

Sex differences in experimental autoimmune encephalomyelitis in multiple murine strains

Innate and adaptive immune requirements for induction of autoimmune demyelinating disease by molecular mimicry

Astrocytic beta2-adrenergic receptors and multiple sclerosis

Beta 2-adrenoceptor involvement in inflammatory demyelination and axonal degeneration in multiple sclerosis

Human proteolipid protein (PLP) mediates winding and adhesion of phospholipid membranes but prevents their fusion

Aberrant forms of alpha(2)-macroglobulin purified from patients with multiple sclerosis

Flow cytometric differentiation of Asian and Western types of multiple sclerosis, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and hyperIgEaemic myelitis by analyses of memory CD4 positive T cell subsets and NK cell subsets