Multiple sclerosis and cognition: synaptic failure and network dysfunction

Nature Reviews. Neuroscience
Massimiliano Di FilippoPaolo Calabresi

Abstract

Cognitive impairment is increasingly recognized to be a core feature of multiple sclerosis (MS), with important implications for the everyday life of individuals with MS and for disease management. Unfortunately, the exact mechanisms that underlie this cognitive impairment are poorly understood and there are no effective therapeutic options for this aspect of the disease. During MS, focal brain inflammatory lesions, together with pathological changes of both CNS grey matter and normal-appearing white matter, can interfere with cognitive functions. Moreover, inflammation may alter the crosstalk between the immune and the nervous systems, modulating the induction of synaptic plasticity and neurotransmission. In this Review, we examine the CNS structures and cognitive domains that are affected by the disease, with a specific focus on hippocampal involvement in MS and experimental autoimmune encephalomyelitis, an experimental model of MS. We also discuss the hypothesis that, during MS, immune-mediated alterations of synapses' ability to express long-term plastic changes may contribute to the pathogenesis of cognitive impairment by interfering with the dynamics of neuronal networks.

References

Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Jan 1, 1997·Brain : a Journal of Neurology·J FoongM A Ron
Feb 17, 1999·The Journal of Neuropsychiatry and Clinical Neurosciences·J FoongM A Ron
Sep 18, 1999·Science·R C Malenka, R A Nicoll
Apr 17, 2002·Lancet·Alastair Compston, Alasdair Coles
Sep 29, 2004·Neuron·Robert C Malenka, Mark F Bear
Oct 30, 2004·Journal of Clinical and Experimental Neuropsychology·John DeLucaNancy D Chiaravalloti
Feb 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Giulia D'IntinoLaura Calzà
Apr 19, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·A AchironY Harel
Nov 30, 2005·Annals of Neurology·Subramaniam Sriram, Israel Steiner
Mar 28, 2006·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Jean LengenfelderJohn DeLuca
Jul 21, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Neal Lemon, Denise Manahan-Vaughan
Sep 20, 2006·Journal of the International Neuropsychological Society : JINS·Ralph H B BenedictBianca Weinstock-Guttman
Sep 19, 2007·Neurology·M K HoutchensR Bakshi
Oct 6, 2007·Nature Reviews. Immunology·Alan G Baxter
Apr 1, 2008·Brain : a Journal of Neurology·N L SicotteS Y Bookheimer
May 22, 2008·Brain Pathology·Dimitrios PapadopoulosRichard Reynolds
Sep 4, 2008·Journal of the International Neuropsychological Society : JINS·J A B MacnivenC S Constantinescu
Oct 3, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·R H B BenedictR Zivadinov
Oct 28, 2008·Brain : a Journal of Neurology·R A DineenD P Auer
Nov 15, 2008·Lancet Neurology·Nancy D Chiaravalloti, John DeLuca
Jan 23, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fabrizio GardoniMonica Di Luca
Jun 16, 2009·Behavioural Brain Research·Fabrício Luiz AssiniReinaldo Naoto Takahashi
Sep 16, 2009·Archives of Neurology·Massimiliano CalabreseMassimo Filippi
Dec 10, 2009·Multiple Sclerosis : Clinical and Laboratory Research·Valentina ZipoliMaria Pia Amato
Mar 3, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Mathilde DeloireBruno Brochet
Mar 20, 2010·Archives of Physical Medicine and Rehabilitation·Maria T SchultheisScott R Millis
Jul 14, 2010·Brain, Behavior, and Immunity·C HeesenS M Gold
Sep 8, 2010·Annals of Neurology·Mario CibelliMervyn Maze
Sep 11, 2010·The Clinical Neuropsychologist·Sarah A MorrowRalph H B Benedict
Oct 15, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Francesco MoriDiego Centonze
Oct 26, 2010·Brain, Behavior, and Immunity·Raz Yirmiya, Inbal Goshen
Jan 14, 2011·Journal of Clinical and Experimental Neuropsychology·Victoria M LeavittJohn DeLuca
Mar 5, 2011·Multiple Sclerosis : Clinical and Laboratory Research·David BakerSandra Amor
Mar 30, 2011·Annals of Neurology·Ranjan DuttaBruce D Trapp
Apr 27, 2011·Current Opinion in Neurology·Dawn W Langdon
Jul 29, 2011·Journal of Neurophysiology·Randy L BucknerB T Thomas Yeo
Jan 21, 2012·Neurology·M P AmatoUNKNOWN Italian RIS/MS Study Group
Feb 16, 2012·Nature Reviews. Neuroscience·John LismanSridhar Raghavachari

❮ Previous
Next ❯

Citations

Feb 28, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Yeona Kang, Susan A Gauthier
Feb 15, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Roisin McMackinOrla Hardiman
Jan 5, 2020·Expert Opinion on Therapeutic Targets·Alessandra MusellaGeorgia Mandolesi
Aug 31, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Luca Prosperini, Massimiliano Di Filippo
Jul 25, 2019·Neurology·James F Sumowski, Nils Muhlert
May 7, 2020·Nature Reviews. Neurology·John DeLucaBrian M Sandroff
Apr 11, 2019·Frontiers in Pharmacology·Jiaying WangQiaojun He
May 28, 2019·Journal of Neurology·Lorenzo GaetaniMassimiliano Di Filippo
May 20, 2020·BMC Neurology·Seyed-Mahdi Khaligh-RazaviSeyed Massood Nabavi
Jul 14, 2020·Frontiers in Cellular Neuroscience·Antonio BrunoGeorgia Mandolesi
Jan 16, 2020·International Journal of Molecular Sciences·Masamichi NagaeYasuhiko Kizuka
Jul 2, 2020·Arquivos de neuro-psiquiatria·Ugo Nocentini
Apr 17, 2019·Nature Reviews. Neurology·Katrin PapeFrauke Zipp
Mar 22, 2019·Biomedicines·Miguel Ángel Macías Islas, Ethel Ciampi
Mar 27, 2020·American Journal of Human Biology : the Official Journal of the Human Biology Council·Nadia Najafi, Maryam Peymani
Aug 23, 2020·International Journal of Molecular Sciences·Maria V Pinto, Adelaide Fernandes
Mar 14, 2019·Frontiers in Cellular Neuroscience·Christopher M HenstridgeRosa C Paolicelli
May 28, 2019·Metabolic Brain Disease·Behnaz Salek EsfahaniMaryam Rezazadeh
Aug 9, 2020·Journal of Molecular Neuroscience : MN·Tobore Onojighofia Tobore
Aug 1, 2020·Frontiers in Neurology·Mario Stampanoni BassiEnnio Iezzi
Aug 14, 2020·Neural Regeneration Research·Lorenzo GaetaniMassimiliano Di Filippo
Oct 6, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Dániel VerébZsigmond Tamás Kincses
Nov 17, 2020·Frontiers in Neurology·Elisabet Lopez-SoleySara Llufriu
Nov 27, 2020·Human Brain Mapping·Martin SjøgårdXavier De Tiège
Feb 3, 2021·The International Journal of Neuroscience·Triantafyllos DoskasΚonstantinos Vadikolias
Nov 24, 2020·Multiple Sclerosis and Related Disorders·Catarina Barros, Adelaide Fernandes
Mar 23, 2020·Multiple Sclerosis and Related Disorders·Vicki E MaltbyJeannette Lechner-Scott
Mar 5, 2021·The Journal of Experimental Medicine·Marcel S WooManuel A Friese
Feb 28, 2021·Journal of the Neurological Sciences·Tehila Eilam-StockLeigh E Charvet
Jan 6, 2021·NeuroImage. Clinical·Josephine HeineCarsten Finke
May 7, 2021·Frontiers in Immunology·Andrea ManciniMassimiliano Di Filippo
Jun 10, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Antonio CarotenutoFrancesco Saccà

❮ Previous
Next ❯

Software Mentioned

PASAT

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here