Multiple sclerosis-associated agent: transmission to animals and some properties of the agent.

Infection and Immunity
U KoldovskyG Haase

Abstract

In confirmation and extension of observations by Carp and his associates, brain tissue and sera from patients with multiple sclerosis (MS) were found to harbor an agent which induces a transitory depression in polymorphonuclear leukocytes (PMN) in mice as well as in rats, hamsters, and guinea pigs. All of eight MD brains contained this agent at titers as high as 10(-9)/g of brain tissue. The agent was found in MS sera at titers up to 10(-3)/ml of serum, but its presence depended to some extent on the clinical status of the patients; it was observed more frequently in sera of patients with active disease (73%) thatn in sera of patients with quiescent disease (31%). Control brain tissues or sera failed to induce PMN depression. The apparently MS-associated agent (MSAA) passed through 50-nm but not 25-nm membrane filters (Millipore Corp.) and was largely sedimented at 105,000 X g but not at 50,000 X g for 1 h. It multiplied to high titers in the central nervous tissue of the inoculated animals and could be serially transmitted from animal to animal by passage of brain homeganates. Various observations and considerations appear to preclude that MS-associated agent represents an indigenous animal virus. Although its role in MS remai...Continue Reading

References

Dec 1, 1951·Proceedings of the Society for Experimental Biology and Medicine·E S RUSSELLC T HIGGINS

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Citations

Dec 1, 1976·Acta Pathologica Et Microbiologica Scandinavica. Section C, Immunology·P PlatzC Jersild
Aug 1, 1977·Journal of Neurology, Neurosurgery, and Psychiatry·F R Ames, S Louw
Jan 1, 1980·Acta Neurologica Scandinavica·I R MackayW W Tourtelotte
Jun 24, 1976·The New England Journal of Medicine·M S Hirsch
Dec 1, 1980·Journal of Epidemiology and Community Health·D C PoskanzerL B Prenney
Sep 1, 1977·Bacteriological Reviews·E M Morgan, F Rapp

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