Multiple sclerosis: current pathophysiological concepts

Laboratory Investigation; a Journal of Technical Methods and Pathology
D M WingerchukJ H Noseworthy

Abstract

Multiple sclerosis (MS) is an often disabling disease primarily affecting young adults that exhibits extraordinary clinical, radiological, and pathological heterogeneity. We review the following: (a) known environmental and genetic factors that contribute to MS susceptibility; (b) current knowledge regarding fundamental pathophysiological processes in MS, including immune cell recruitment and entry into the central nervous system (CNS), formation of the plaque, and orchestration of the immune response; (c) descriptive and qualitative distinct pathological patterns in MS and their implications; (d) the evidence supporting the causative role of direct toxins, cell-mediated and humorally mediated immune mechanisms, and the concept of a "primary oligodendrogliopathy" in demyelination and axonal injury; (e) the potential benefits of inflammation; (f) the prospects for remyelination; and (g) therapeutic implications and approaches suggested by putative pathophysiological mechanisms.

References

Dec 2, 1975·Journal of Neurology·A Guseo, K Jellinger
Aug 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·K SelmajC S Raine
Mar 1, 1991·The Journal of Clinical Investigation·K SelmajC F Brosnan
Jun 1, 1991·Brain : a Journal of Neurology·D BarnesW I McDonald
Jan 1, 1990·Annals of Neurology·M Rodriguez, V A Lennon
Feb 1, 1989·Journal of Neuroimmunology·Y GrenierJ P Antel
Jul 1, 1988·Neurology·M F Mendez, S Pogacar
Dec 25, 1986·The New England Journal of Medicine·G C EbersT Grey
Nov 1, 1995·Annals of Neurology·W BrückH Lassmann
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·T TsuchidaW E Biddison
Apr 1, 1995·Annals of Neurology·B Cannella, C S Raine
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·P B ChallonerM Chang
Jan 1, 1993·The Journal of Experimental Medicine·J L BaronC A Janeway
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·H KoprowskiB Dietzschold
Nov 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·B G van EngelenM Rodriguez
Sep 1, 1994·The Journal of Experimental Medicine·D UnutmazS Abrignani
Jan 1, 1994·Ultrastructural Pathology·M Rodriguez, B Scheithauer
Jan 1, 1994·Neurology·C J MumfordD A Compston
Mar 1, 1993·Annals of Neurology·A D SadovnickT J Murray
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·O BagasraH Koprowski
May 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A C Cato, E Wade
Aug 1, 1996·Nature Genetics·G C EbersN Risch
Mar 1, 1996·Journal of Neuropathology and Experimental Neurology·A Maeda, R A Sobel
Dec 15, 1995·Neuroscience Letters·S ChandlerE Bone
Aug 15, 1996·Journal of Neuroscience Research·V Navikas, H Link
Oct 31, 1996·Nature·A K AbbasA Sher

❮ Previous
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Citations

Jun 11, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chandramohan Natarajan, John J Bright
Apr 1, 2003·Expert Opinion on Investigational Drugs·Heinz Wiendl, Bernd C Kieseier
May 8, 2004·Brain : a Journal of Neurology·Jagat R KanwarGeoffrey W Krissansen
Aug 28, 2004·The Journal of Pharmacology and Experimental Therapeutics·Mirentxu I IruretagoyenaAlexis M Kalergis
Dec 2, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Vincenza SofoPlacido Bramanti
Feb 21, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·David J Virley
Dec 17, 2009·The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses·Pamela K NewlandMargaret Ullione
Jul 14, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Aaron P KithcartCaroline C Whitacre
Jul 31, 2012·Case Reports in Pediatrics·Regina Célia Ajeje Pires de AlbuquerqueLucas Crociati Meguins
Jun 26, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gina Mavrikis CoxCaroline C Whitacre
Jan 15, 2017·Journal of Neuroinflammation·Charbel MoussaR Scott Turner
Jan 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Richard E JonesDennis Bourdette
Nov 25, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Istvan PirkoMoses Rodriguez
May 6, 2003·Annals of Neurology·Jennifer L TakahashiV Wee Yong
Dec 21, 2005·Brain : a Journal of Neurology·Leonie A BovenJon D Laman
May 22, 2003·Acta Neurologica Scandinavica·M BilinskaE Gruszka
Nov 25, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chandramohan NatarajanJohn J Bright
Aug 2, 2008·PPAR Research·John J BrightSharmistha Chakraborty
Nov 20, 2009·The International Journal of Neuroscience·K Jovanova-NesicN Herbert Spector
Dec 14, 2012·Multiple Sclerosis : Clinical and Laboratory Research·Ayse KuspinarNancy E Mayo
Dec 8, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Michael ValerioAtif B Awad
Jul 21, 2017·Journal of Medical Economics·Melissa A FrascoNina Thomas
Dec 29, 2017·Annals of Neurology·David A GilesBenjamin M Segal
Feb 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Richard E JonesHalina Offner
Nov 13, 2004·European Neurology·Hossein KalanieAmir Reza Kalanie
Apr 15, 2003·Current Neurology and Neuroscience Reports·Dean M Wingerchuk
Mar 5, 2011·Multiple Sclerosis : Clinical and Laboratory Research·Samia RaghebRobert Lisak
Mar 25, 2014·BMC Neurology·Soodeh Razeghi JahromiShadi Ziaie
Jan 24, 2015·Brain : a Journal of Neurology·Jason D HinmanS Thomas Carmichael
Nov 15, 2018·Archives of Pharmacal Research·Seon Min Yoo, Sung Hyun Chung

❮ Previous
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