Multiple sclerosis in a family on the Faroe Islands

Acta Neurologica Scandinavica
S BinzerE Stenager

Abstract

John Kurtzke has proposed that multiple sclerosis (MS) on the Faroe Islands occurred as a result of the spread of a transmittable agent brought to the country during World War II. Kurtzke's theory has been opposed earlier and in this study, we present a family from the Faroe Islands containing a total of 14 family members with MS which show further inconsistencies with the theory. The present study is to our knowledge, the first description of familial incidences of MS on the Faroe Islands. Medical histories were gathered from 12 family members and 6 of the 8 living MS cases were human leukocyte antigen (HLA)-typed. Seven family members had primary progressive MS (PPMS), while five had relapsing remitting MS. The HLA-DR15 allele was carried by the three cases with the most aggressive form of MS and they shared a common haplotypes. The HLA types carried by the remaining cases varied. This research questions Kurtzke's theory as three of the cases do not conform to the epidemic cohorts described. Furthermore, there appears to be a higher than usual prevalence of PPMS. The high degree of heterogeneity of the HLA types carried indicates that HLA alleles do not independently explain the risk of developing MS.

References

Oct 1, 1993·Clinical Microbiology Reviews·J F Kurtzke
Feb 13, 2001·Journal of Clinical Epidemiology·J F Kurtzke, A Heltberg
Apr 15, 2004·Journal of Neuroimmunology·Clara BalleriniSandra D'Alfonso
Aug 23, 2005·Journal of Neuroimmunology·Elisabetta PratRoland Martin
Feb 14, 2007·Multiple Sclerosis : Clinical and Laboratory Research·I A HoppenbrouwersR Q Hintzen
Apr 11, 2008·Genes and Immunity·I A HoppenbrouwersR Q Hintzen
May 8, 2008·Immunogenetics·Arne Svejgaard
Feb 18, 2009·Human Molecular Genetics·Suvi P KallioJanna Saarela

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Citations

Sep 13, 2015·Multiple Sclerosis : Clinical and Laboratory Research·S BinzerK Imrell
Nov 14, 2014·Multiple Sclerosis : Clinical and Laboratory Research·S BinzerE Stenager
Jun 29, 2010·Acta Neurologica Scandinavica·M T Wallin, J F Kurtzke

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