PMID: 9160345Feb 1, 1997Paper

Multiple sclerosis in childhood: clinical features of 149 cases

Multiple Sclerosis : Clinical and Laboratory Research
Angelo GhezziM Zaffaroni

Abstract

From the retrospective study of 3375 patients affected by clinically definite or probable multiple sclerosis (MS), 149 patients were collected with onset of the disease before the age of 16 years (4.4%). Female/male ratio was higher than that of the adult onset MS (AOMS) population (2.2 vs 1.6) particularly at ages of onset after 12 years (3.0, P = 0.007 vs AOMS). Among initial symptoms, those suggesting brainstem dysfunction (25%) were more frequent compared to other systems and compared to AOMs symptoms; motor and sensory disturbances were slightly less frequent (respectively 17.5% and 18.3%). Optic neuritis appeared in 16.5% of cases with onset in childhood and in 16.2% of cases with AOMS, cerebellar disturbances respectively in 9.1% and 7.7%. The first interattack-interval and the clinical course of early onset MS did not differ significantly from AOMS. In early onset MS patients with disease duration < 8 years, cases with EDSS > 6 were slightly more frequent than in the AOMS group (P = 0.04). The frequency of cases for different levels of disability was similar for disease duration > 8 years.

References

Sep 1, 1992·Acta Neurologica Scandinavica·E SindernU Wurster
Nov 1, 1991·Brain & Development·F HanefeldJ Frahm
Sep 1, 1990·Developmental Medicine and Child Neurology·M M MillnerC Urban
Jul 1, 1986·Archives of Neurology·K Birk, R Rudick
Oct 1, 1987·Journal of Child Neurology·C M Shaw, E C Alvord
Sep 1, 1987·The Journal of Pediatrics·P DuquetteW Hader
May 5, 1973·British Medical Journal·D McAlpine
Aug 1, 1984·Archives of Neurology·J M Bejar, D K Ziegler
Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Apr 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·R MidgardH Nyland
Mar 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·M TrojanoP Livrea
Nov 1, 1993·Acta Neurologica Scandinavica·H B van LieshoutW O Renier
Feb 1, 1993·Brain : a Journal of Neurology·B Runmarker, O Andersen
Jan 1, 1996·European Neurology·D SelcenY Renda
Nov 1, 1951·A.M.A. Archives of Neurology and Psychiatry·R MULLER

❮ Previous
Next ❯

Citations

Feb 28, 2006·Journal of Neurology·Olivier DeryckBénédicte Dubois
Apr 23, 2004·Current Neurology and Neuroscience Reports·Brenda L Banwell
Apr 9, 2005·Current Treatment Options in Neurology·Lauren B Krupp, William S Macallister
Dec 12, 2012·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Tanuja Chitnis
Jan 1, 2014·Clinical Neurology and Neurosurgery·Silvia N Tenembaum
Jun 1, 2005·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Vinod PuriDaljit Singh
Mar 24, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Dorothée ChabasEmmanuelle Waubant
Sep 11, 2003·International Journal of Nursing Studies·Gullvi FlensnerOlle Söderhamn
Jul 20, 2002·Clinical Neurology and Neurosurgery·Eugin GusevDonald Paty
May 28, 2003·Brain & Development·Serkan OzakbasBurak Yulug
May 28, 2003·Brain & Development·Natan Gadoth
Aug 30, 2000·Pediatric Neurology·M UenoT Hara
Jan 30, 2002·Pediatric Neurology·Laura C McAdamBrenda L Banwell
Nov 25, 2003·Pediatric Neurology·Steven David BrassBernard Rosenblatt
Jun 22, 2007·The New England Journal of Medicine·Christel RenouxUNKNOWN Adult Neurology Departments KIDMUS Study Group
Mar 2, 2012·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·William S MacAllisterLana Harder
Oct 13, 2007·Developmental Neuropsychology·William S MacAllisterLauren B Krupp
Aug 20, 2010·Developmental Neuropsychology·Ben DeeryAndrew Kornberg
Jul 4, 2012·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·C TillB L Banwell
Jul 31, 2012·Case Reports in Pediatrics·Regina Célia Ajeje Pires de AlbuquerqueLucas Crociati Meguins
Nov 17, 2012·Journal of Child Neurology·Laura JulianUNKNOWN Network of Pediatric MS Centers of Excellence
Apr 21, 2012·Multiple Sclerosis : Clinical and Laboratory Research·Michael AbsoudUNKNOWN UK and Ireland Childhood CNS Inflammatory Demyelination Working Group
Nov 15, 2013·BMC Neurology·Tanuja ChitnisUNKNOWN U.S. Network of Pediatric MS Centers of Excellence
Feb 4, 2011·Neurology·S VenkateswaranUNKNOWN Canadian Pediatric Demyelinating Disease Network
Apr 14, 2004·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Shaun MorrisAleixo Muise
Nov 7, 2013·International Journal of Environmental Research and Public Health·Gonzalo Eguíluz, María Begoña García
Feb 26, 2010·Annals of Indian Academy of Neurology·Yashma PatelLauren Krupp
Apr 30, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Tanuja Chitnis
Jul 31, 1999·Pediatric Neurology·A B AdamsK R Holden
Jul 18, 2014·Journal of the International Neuropsychological Society : JINS·Banafsheh HosseiniChristine Till
Dec 2, 2010·Women's Health·Céline JobinPierre Duquette
Aug 4, 2012·AJNR. American Journal of Neuroradiology·M S VishwasT Chitnis
Sep 14, 2014·Journal of the Neurological Sciences·Elhachmia Ait Ben HaddouMohamed Yahyaoui
Dec 17, 2015·Current Problems in Pediatric and Adolescent Health Care·Sona Narula
Apr 24, 2013·Neuroimaging Clinics of North America·Leonard H VerheyBrenda Banwell
Oct 2, 2012·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Carmen Arnal-GarciaCelia Oreja-Guevara
Jul 15, 2015·European Journal of Pediatrics·Silvia Dell'AvventoStefano Sotgiu
Mar 29, 2011·Neurologic Clinics·Tanuja ChitnisEmmanuelle Waubant
Mar 29, 2011·Neurologic Clinics·Laura J Julian
May 18, 2010·Clinical Neurology and Neurosurgery·Silvia N Tenembaum
Dec 17, 2009·Pediatric Neurology·Rinze F NeuteboomUNKNOWN Dutch Study Group on Childhood Multiple Sclerosis and Acute Disseminated Encephalomyelitis
Sep 21, 2015·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·R LanzilloV Brescia Morra

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.