Multiple sclerosis in French Canadians: evidence for HLA class II susceptibility and resistance genes

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
D G HaegertG S Francis

Abstract

HLA class II DRB1, DQB1 and DQA1 gene probes were used to study DNA from unrelated French Canadian multiple sclerosis (MS) patients and controls by restriction fragment length polymorphism (RFLP) analysis. An MS-associated and linked series of allele-specific RFLPs or allogenotypes was identified among this relatively homogeneous ethnic group; the allogenotypes include DRw15, DQw6 and a DQA1 allogenotype termed DQ alpha 1b. An additional allogenotype which cross-hybridizes with DQA1 and is termed DQA2 upper (DQA2U), was shown not only to be part of the MS-associated extended haplotype, but also to be independently associated with MS in DRw15-negative patients. Conversely a second DQA2 allogenotype, termed DQA2 lower (DQA2L) and a DQB1 allogenotype (DQw7) linked to DQA2L showed negative correlations with MS. It seems likely that the relationship of the HLA class II gene region to MS is complex and that MS susceptibility may reflect interaction between disease susceptibility and resistance genes.

References

May 1, 1990·Journal of Neuroscience Research·D G HaegertG S Francis
May 1, 1989·Journal of Neuroscience Research·D G HaegertG Francis
Jan 25, 1986·Lancet·D A FrancisA W Downie
Jan 1, 1988·Tissue Antigens·A P WeetmanA So
Jan 1, 1988·Annals of the New York Academy of Sciences·T A CiullaS L Hauser
Jan 1, 1988·Immunology Today·J Bidwell
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J R OksenbergL Steinman
Jul 1, 1985·Immunological Reviews·J TrowsdaleJ Bodmer
Jul 3, 1986·Nature·H FestensteinJ A Sachs
Dec 25, 1986·The New England Journal of Medicine·G C EbersT Grey
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·D CohenJ Dausset
Jan 1, 1984·Annals of the New York Academy of Sciences·H F McFarlandH Krebs
Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte

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Citations

Dec 1, 1994·Annals of Neurology·D G Haegert, M G Marrosu
Jun 1, 1993·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·V LepageD Charron

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