Multiple sclerosis in the Republic of San Marino: a prevalence and incidence study

Multiple Sclerosis : Clinical and Laboratory Research
E GranieriI Casetta

Abstract

Studies on the distribution of multiple sclerosis (MS) carried out in Southern Europe in the last years have shown a significant increase in the frequency of the disease. A previous descriptive survey in the Republic of San Marino, northern Italian peninsula, published in 1984 established that this area is at high risk for MS. We updated the frequency estimates of the disease by adopting a complete enumeration approach. On 31 December 2005, 50 MS patients (36 women and 14 men) yielded a crude prevalence rate of 166.7 per 100, 000 (95% CI 123.7-220), 235.3 (95% CI 165-327.4) for women and 95.2 (95% CI 52-160) for men. The average incidence from 1990 to 2005 was 7.9 (95% CI 5.3-11.1) per 100,000, 11.7 (95% CI 7.6-17.3) for women and 3.9 (95% CI 1.7-7.7) for men. We did not detect any significant temporal trend over the study period. These results confirm that in San Marino the disease occurs more frequently than that suggested in the past and support the data on MS frequency in continental Italy. The marked increase in MS prevalence ratio is partly due to the increasing survival of patients and the accumulation of new incidence cases owing to the reduction in diagnostic latency for better quality of neurological diagnostic proced...Continue Reading

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Citations

Sep 28, 2013·BMC Neurology·Elaine KingwellRuth Ann Marrie
Sep 13, 2013·Multiple Sclerosis International·Nicola Luigi Bragazzi
Dec 16, 2010·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Scott SlokaV Wee Yong
Oct 20, 2011·European Journal of Gastroenterology & Hepatology·Kadri LillemäeOivi Uibo
Mar 18, 2010·International Review of Psychiatry·Ephrosyni KoutsourakiStavros Baloyannis
Dec 22, 2014·BMC Neurology·Joao de SáJesús de Pedro-Cuesta
Jan 3, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A GajofattoM D Benedetti
Aug 12, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Claude M J Braun, Carl Roberge
Jan 15, 2014·Multiple Sclerosis : Clinical and Laboratory Research·Kjetil BjørnevikMaura Pugliatti
Nov 13, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Alessandra NicolettiMario Zappia
Oct 7, 2009·Multiple Sclerosis : Clinical and Laboratory Research·Inger BoströmAnne-Marie Landtblom
Feb 3, 2012·Multiple Sclerosis : Clinical and Laboratory Research·A FromontT Moreau
Apr 20, 2013·Multiple Sclerosis : Clinical and Laboratory Research·M PuthenparampilUNKNOWN Multiple Sclerosis Epidemiology Veneto Study Group (MuSEV)
Oct 12, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Daiana BezziniPaolo Francesconi
Jan 4, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Mario Alberto Battaglia, Daiana Bezzini

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