Multiple sclerosis: management issues during pregnancy

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Simone FerreroNicola Ragni

Abstract

Care of pregnant women with multiple sclerosis (MS) is challenging because of the multiple physiological changes associated with pregnancy and the need to consider the impact of any intervention on the foetus. Pregnancy is associated with clinical MS stability or improvement, while the rate of relapse rises significantly during the first three months post-partum before coming back to its level prior to pregnancy. Gestational history has no influence on long-term disability and MS does not seem to influence pregnancy or the child's health. Apart from methotrexate and cyclophosphamide, most drugs used regularly to treat MS can safely be used by pregnant women. Intravenous steroids may be used with relative safety during pregnancy. Maternal use of azathioprine is not associated with an increased risk of congenital malformations, though impaired foetal immunity, intrauterine growth retardation and prematurity are occasionally observed. Cyclosporin is not teratogenic, but may be associated with growth retardation and prematurity. Pregnancy should be avoided in women treated with methotrexate because of its known abortifacient effects and risk of causing typical malformations. Cyclophosphamide is teratogenic in animals, but populatio...Continue Reading

References

Nov 1, 1991·Acta Neurologica Scandinavica·S BernardiC Fieschi
Jul 1, 1990·Archives of Neurology·K BirkR A Rudick
Jun 17, 1988·JAMA : the Journal of the American Medical Association·L M NelsonM C Jones
Aug 1, 1986·Neurology·D S ThompsonG M Franklin
Jan 1, 1985·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·H ErkkiläM Gummerus
Sep 1, 1966·Brain : a Journal of Neurology·K SchapiraH Miller
Nov 9, 1984·JAMA : the Journal of the American Medical Association·C L MurrayL B Twiggs
Aug 1, 1984·Annals of Neurology·I Korn-LubetzkiO Abramsky
Nov 1, 1983·Neurology·S Poser, W Poser
Jun 1, 1983·Anesthesia and Analgesia·J S Crawford
Dec 1, 1980·The American Journal of Medicine·J BlattD G Poplack
Feb 1, 1994·Teratology·A E DonnenfeldG Koren
Feb 1, 1994·Clinical Neurology and Neurosurgery·P VerdruH Carton
Feb 1, 1994·Journal of Neurology·J WorthingtonA Forti
Oct 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·E RoulletR Marteau
Dec 1, 1995·Arthritis and Rheumatism·B L Bermas, J A Hill
Jul 31, 1998·The New England Journal of Medicine·J N Whitaker
Apr 17, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·R OrvietoA Achiron
Mar 21, 2002·American Journal of Obstetrics and Gynecology·Beth A MuellerCathy W Critchlow
Oct 5, 2006·Current Opinion in Anaesthesiology·Ihab R Dorotta, Armin Schubert

❮ Previous
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Citations

Aug 8, 2009·Der Nervenarzt·S SchwarzB Storch-Hagenlocher
Feb 8, 2006·Archives of Gynecology and Obstetrics·Krzysztof M Kuczkowski
Apr 15, 2008·Journal of Neurology·Kerstin HellwigRalf Gold
Aug 29, 2012·Journal of Neurology·Maria K Houtchens, Channa M Kolb
Oct 22, 2009·Clinical Reviews in Allergy & Immunology·Norbert Gleicher
Feb 24, 2005·Clinical Obstetrics and Gynecology·Kelly A Bennett
Dec 25, 2004·Obstetrical & Gynecological Survey·P J van Runnard HeimelH W Bruinse
Dec 6, 2005·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·F SellebjergUNKNOWN EFNS Task Force on Treatment of Multiple Sclerosis Relapses
Jan 2, 2013·BMC Neurology·Luisa PastòUNKNOWN MS Study Group of the Italian Neurological Society
Jun 6, 2014·PloS One·Nadja BorisowJan Dörr
Aug 29, 2012·Clinical Ophthalmology·John H Pula, Christopher J Macdonald
Apr 2, 2014·Revue neurologique·E BodiguelJ De Seze
Sep 19, 2008·La Revue de médecine interne·J-C Weber, C Kuhnert
Jul 5, 2012·Women's Health·Sura Alwan, A Dessa Sadovnick
Sep 22, 2007·Anesthesiology Clinics·Ansgar M Brambrink, Jeffrey R Kirsch
Dec 28, 2007·Patient Education and Counseling·Martine C PruntyGary Fulcher
Jan 18, 2007·Neurotoxicology·M De SantisA Caruso
Jul 1, 2014·TheScientificWorldJournal·Ioan Buraga, Roxana-Elena Popovici
Jan 22, 2008·Acta Neurologica Scandinavica·K HellwigR Gold
Apr 28, 2006·Acta Neurologica Scandinavica. Supplementum·J DahlN E Gilhus
Oct 5, 2012·Annals of Neurology·Jorge CorrealeMaría C Ysrraelit
Apr 9, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Maki KohHiroshi Tamai
Apr 16, 2011·Acta Neurologica Scandinavica·I A HoevenarenF K Lotgering
Apr 18, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Maki KohHiroshi Tamai
Jan 18, 2006·Clinical Neurology and Neurosurgery·Sandra Vukusic, Christian Confavreux
May 15, 2016·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Evelyn Brandt-WoutersRaymond M M Hupperts
Apr 1, 2017·Disability and Rehabilitation·Catherine Louise WillsonSara MacKian
Mar 24, 2017·Expert Opinion on Drug Safety·Jan ThöneKerstin Hellwig
Apr 29, 2016·Journal of Perinatal Medicine·Serenat Eris YalcinMekin Sezik
Jul 12, 2007·Multiple Sclerosis : Clinical and Laboratory Research·V De Las HerasUNKNOWN EMPATIE Study Group
Aug 15, 2008·Multiple Sclerosis : Clinical and Laboratory Research·E CoccoUNKNOWN FEMIMS Group
Jan 16, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Bruce A C Cree
Mar 21, 2009·Multiple Sclerosis : Clinical and Laboratory Research·N Fernández LiguoriA Villa
Mar 26, 2009·Multiple Sclerosis : Clinical and Laboratory Research·Y H ChenH C Lin
Sep 21, 2007·Multiple Sclerosis : Clinical and Laboratory Research·Judith Haas, Otto Roelf Hommes
Nov 20, 2008·Reproductive Sciences·Andreas A Argyriou, Nicolaos Makris
Jan 12, 2011·Multiple Sclerosis : Clinical and Laboratory Research·Magnhild Sandberg-WollheimGabrielle Kornmann
Apr 26, 2011·Epidemiology·Nete Munk NielsenMorten Frisch
Aug 31, 2018·American Journal of Epidemiology·Sarah C MacDonaldSonia Hernández-Díaz
May 7, 2008·Current Opinion in Anaesthesiology·Vibeke Moen, Lars Irestedt
Mar 29, 2019·The Medical Journal of Australia·Anneke Van Der WaltVilija Jokubaitis
May 29, 2008·Expert Review of Neurotherapeutics·Angelo Ghezzi, Mauro Zaffaroni
Aug 5, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Maria Pia AmatoGiancarlo Comi
Sep 1, 2018·Neurology and Therapy·Yara Dadalti FragosoClaudia Cristina F Vasconcelos
Aug 3, 2020·Journal of Molecular Neuroscience : MN·Niyousha SadeghpourVahid Shaygannejad

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