Multiple sclerosis: oligodendrocytes in active lesions do not express class II major histocompatibility complex molecules.

Journal of Neuroimmunology
S C Lee, C S Raine

Abstract

The expression of major histocompatibility complex (MHC) molecules by oligodendrocytes has been proposed as evidence for their involvement in the multiple sclerosis (MS) lesion although the literature on the subject is controversial and based largely upon observations in vitro. With a modified immunocytochemical procedure on 1 micron epoxy sections, the present study has examined the expression of class II MHC molecules (Ia) on cells within actively demyelinating lesions in a central nervous system biopsy from a case of acute MS. White Ia was readily demonstrable on microglial cells and astrocytes, it was never detected on adjacent surviving oligodendrocytes. Unexpectedly, in parallel sections, the oligodendrocytes stained positively for myelin-associated glycoprotein, a marker for immature oligodendrocytes. The unequivocal lack of Ia expression by oligodendrocytes in MS makes it unlikely that they serve as immunomodulators in lesion pathogenesis.

References

Dec 1, 1977·The New England Journal of Medicine·O AbramskyD E Pleasure
Mar 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·N H SternbergerH D Webster
Jun 1, 1985·Journal of Neuroimmunology·S U Kim
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R P SanetoJ de Vellis
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J P TingJ A Frelinger
Aug 23, 1984·Nature·G H WongJ W Schrader
Jan 1, 1984·Annals of the New York Academy of Sciences·J W PrineasL R Sharer
Jan 1, 1987·Immunology Today·L H Glimcher, I J Griffith

❮ Previous
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Citations

Sep 1, 1991·Neurochemical Research·D Baker, A N Davison
Jun 15, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Burkhard BecherMelanie Greter
Feb 19, 2008·Journal of Molecular Neuroscience : MN·T Zeis, N Schaeren-Wiemers
Jan 1, 1990·Neuroscience·J M LawrenceG Raisman
May 26, 1998·Journal of the Neurological Sciences·B G Xiao, H Link
Jan 13, 2000·Neuropathology and Applied Neurobiology·J E Merrill, N J Scolding
Aug 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·K SelmajC S Raine
Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·K BergsteindottirR Mirsky
Nov 1, 1994·The Journal of Experimental Medicine·K BankiA Perl
Dec 1, 1996·The Journal of Experimental Medicine·S D D'SouzaJ P Antel
Aug 1, 1991·Neuropathology and Applied Neurobiology·C S Raine
Jul 25, 2006·Journal of Neuroinflammation·Esther ZeinstraJacques De Keyser
Nov 8, 2005·Proceedings of the National Academy of Sciences of the United States of America·Katharine A WhartenbyDonald Small
Apr 20, 2001·Journal of Neuroimmunology·R H MorseJ P Antel
Mar 1, 2000·Journal of Neuroimmunology·K A Sabelko-DownesA H Cross
Jan 1, 2007·Expert Review of Clinical Immunology·Bettina SchreinerStephen D Miller
Sep 14, 2018·Brain : a Journal of Neurology·David BakerKlaus Schmierer
Nov 6, 2018·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ari Waisman, Lisa Johann
Nov 14, 2018·Nature Medicine·Ana Mendanha FalcãoGonçalo Castelo-Branco
Nov 15, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rebecca A SosaThomas G Forsthuber
Nov 1, 1993·Journal of Neuroscience Research·K WilliamsJ P Antel
Feb 12, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fatma ZaguiaNathalie Arbour
Jan 1, 1992·International Reviews of Immunology·J ZhangD A Hafler
Mar 1, 1994·Annals of Neurology·J P AntelJ McLaurin
Nov 10, 2020·Seminars in Cell & Developmental Biology·Leslie Kirby, Gonçalo Castelo-Branco
Aug 22, 2021·Proceedings of the National Academy of Sciences of the United States of America·Catherine LarochelleFrauke Zipp

❮ Previous
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