PMID: 8964914May 1, 1996Paper

Multiple sclerosis: prospective analysis of TNF-alpha and 55 kDa TNF receptor in CSF and serum in correlation with clinical and MRI activity

Journal of Neuroimmunology
S SpulerR Hohlfeld

Abstract

The possibility of antagonizing tumor necrosis factor-alpha (TNF-alpha) in vivo with antibodies or soluble TNF receptor has focused much interest on the role of this cytokine in the natural course of MS. We studied nine patients prospectively and serially for one year (14 time points, 131 observations). TNF-alpha and the 55 kDa soluble TNF receptor were measured every 4 weeks in the serum and at defined time points in the CSF. Each value was correlated to clinical symptoms and to MRI measurements obtained on the same day. All patients with relapsing-remitting disease showed periodic increases of TNF concentrations. Overall, the association between serum TNF-alpha levels and bursts of Gd-DTPA enhancement on cranial MRI was not sufficiently tight to reach statistical significance. However, serum TNF levels > 50 pg/ml and measurable CSF levels were always associated with Gd-DTPA enhancing MRI lesions. Isolated high serum TNF peaks were noted during episodes of infection, hay fever or psychic stress. After treatment with glucocorticoids, TNF levels were suppressed for several months, whereas new Gd-DTPA enhancing lesions continued to appear. The concentrations of the soluble 55 kDa TNF receptor did not show marked fluctuations. The...Continue Reading

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Citations

Dec 12, 1997·Journal of the Neurological Sciences·G MartinoL M Grimaldi
Sep 3, 1998·Journal of Neuroimmunology·P A CalabresiE P Cowan
Aug 27, 1998·Neuroscience Letters·J DrulovićV Pravica
Aug 5, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A BertolottoR Mutani
Aug 12, 2004·Biological & Pharmaceutical Bulletin·Hirotomo AkabaneHiroichi Nagai
Sep 1, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H DaiU Costabel
Feb 14, 2007·Acta Neurologica Scandinavica·E Kamali-SarvestaniB Gharesi-Fard
Jun 4, 2015·PloS One·Marta Tejera-AlhambraSilvia Sánchez-Ramón
May 13, 2011·Multiple Sclerosis : Clinical and Laboratory Research·Sabine LindquistMichael Sailer
Oct 2, 2009·Nature Reviews. Neurology·Tania Kümpfel, Reinhard Hohlfeld
Jan 15, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·I V SmaginaL P Galaktionova
Jan 30, 2020·International Journal of Molecular Sciences·Lalita SubediSun Yeou Kim
May 28, 2019·Neuropathology and Applied Neurobiology·A GentileA Musella
Feb 29, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J L CroxfordD Baker
Jul 27, 2005·Multiple Sclerosis : Clinical and Laboratory Research·J S Sloka, M Stefanelli

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