Multiple sclerosis recurrence risk for siblings in an isolated population of Central Sardinia, Italy

Genetic Epidemiology
Cristina MontomoliLuisa Bernardinelli

Abstract

Studies of twins, adoptees, half siblings, and familial recurrence risk have shown that genetic and non-genetic factors are involved in multiple sclerosis (MS) etiology. Age at onset, gender, and parental MS status seem to influence sibling risk. We studied the recurrence risk in siblings of MS patients in an isolated population of Sardinia, Italy, which is genetically homogeneous, inbred, and very stable, with a high MS frequency. The Aalen-Nelson estimate of the recurrence risk in siblings is 4.7%, and the risk ratio compared with the general population is 31. Proportional hazards models were used to investigate the effect of sibling sex, sex, and age at onset of the proband, and number of affected relatives on a sibling's predicted MS risk. Sib's risk is influenced by age at onset (P = 0.02), and possibly by sex of the proband (P = 0.08). There is also a borderline significant interaction (P = 0.05) between the sex and age at onset of the proband: early age at onset influences sib's risk only if the proband is female. The number of affected relatives in the family is not found to influence sibling risk, but the power is lacking (95% CI 0.50-2.62). This result is consistent with a single dominant gene with an extremely low pe...Continue Reading

References

Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Jan 1, 1995·Critical Reviews in Clinical Laboratory Sciences·R Martin, H F McFarland
Aug 1, 1996·Neurology·N P RobertsonD A Compston
Apr 1, 1996·Brain : a Journal of Neurology·N P RobertsonD A Compston
Apr 14, 1997·American Journal of Medical Genetics·F Vogel
Apr 1, 1997·Journal of Neurology, Neurosurgery, and Psychiatry·H CartonA D Sadovnick
Jan 10, 2001·Clinical Genetics·A D SadovnickUNKNOWN Canadian Collaborative Study Group
Mar 29, 2001·Neurology·A Dessa SadovnickUNKNOWN Canadian Collaborative Study Group

❮ Previous
Next ❯

Citations

Jan 30, 2004·Lancet Neurology·David A DymentA Dessa Sadovnick
Jan 14, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·F Martinelli-BoneschiG Comi
May 31, 2007·PloS One·Luisa BernardinelliCarlo Berzuini
Aug 14, 2009·Journal of the Neurological Sciences·Maura PugliattiTrond Riise
Oct 12, 2004·Neurobiology of Disease·Stefano SotgiuGiulio Rosati
Apr 30, 2015·Multiple Sclerosis : Clinical and Laboratory Research·A HadjixenofontosJ L McCauley
Aug 27, 2005·American Journal of Epidemiology·Nete Munk NielsenMads Melbye
Dec 24, 2018·Journal of Neurology·Jie SongAli Manouchehrinia

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.