Multiple sclerosis-related cognitive changes: a review of cross-sectional and longitudinal studies

Journal of the Neurological Sciences
Maria Pia AmatoEmilio Portaccio

Abstract

Prevalence estimates of cognitive impairment in multiple sclerosis (MS) range from 40% to 65%, depending on the research setting. Cognitive dysfunction virtually encompasses all the disease stages and types of clinical course, although it is generally less frequent in relapsing-remitting (RR) patients compared with secondary progressive (SP) patients, and tends to be less frequent in primary progressive (PP) patients. Moreover, it causes role limitations in work and social life, independently of the degree of physical disability. Relatively little is known about the evolution of cognitive impairment in MS, particularly starting from the early stages of the disease. Controlled studies, however, have clearly shown that cognitive deterioration tends to progress over time. Among clinical predictors, incipient cognitive decline seems to be the major risk factor for further deterioration in the short-term. In the long-term, the likelihood increases that also patients with initial cognitive preservation may deteriorate. As for magnetic resonance imaging (MRI), there are consistent, albeit moderate, correlations between the progression of cognitive impairment and increasing brain lesion load and brain atrophy. The aim of this paper is ...Continue Reading

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References

Apr 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·S A Montgomery, M Asberg
Aug 1, 1979·Rheumatology and Rehabilitation·D Staples, N B Lincoln
Nov 1, 1991·The British Journal of Clinical Psychology·S A McIntosh-MichaelisA J Spackman
Feb 1, 1991·Psychological Medicine·M A RonE K Warrington
Nov 1, 1990·Journal of the Neurological Sciences·A Jennekens-SchinkelE A van der Velde
Aug 1, 1990·Journal of Clinical and Experimental Neuropsychology·S L MindenP Reich
Nov 1, 1986·Archives of Neurology·O Lyon-CaenF Lhermitte
Jan 1, 1970·Acta Neurologica Scandinavica·J F Kurtzke
Jul 1, 1969·The British Journal of Psychiatry : the Journal of Mental Science·D Surridge
Jun 1, 1984·Archives of Neurology·S M RaoD Lloyd
Jul 1, 1983·American Journal of Ophthalmology·P BobakJ Thornton
Sep 1, 1980·Archives of Neurology·J M PeyserS B Filskov
Apr 1, 1993·Neurology·M P AmatoL Amaducci
Jun 1, 1993·Brain : a Journal of Neurology·A FeinsteinA Thompson
Feb 1, 1997·Brain : a Journal of Neurology·P KujalaJ Ruutiainen
Sep 11, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J Benito-LeónJ Rivera-Navarro
Mar 18, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·A Achiron, Y Barak
Jun 25, 2003·The Clinical Neuropsychologist·William W Beatty, Robin L Aupperle
Apr 1, 1957·The Journal of Nervous and Mental Disease·O A PARSONSD ARENBERG
Mar 19, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·R J Siegert, D A Abernethy
Nov 11, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·R VetrugnoP Montagna
Dec 8, 2009·Multiple Sclerosis : Clinical and Laboratory Research·Emilio PortaccioMaria Pia Amato

❮ Previous
Next ❯

Citations

Sep 16, 2009·Archives of Neurology·Nathan P StaffB Mark Keegan
Sep 17, 2009·Journal of Neurology·Lisa HolperJürg Kesselring
Aug 27, 2010·Journal of Neurology·Sebastian HorowskiUwe Walter
Mar 5, 2011·Journal of Neurology·Michaela CoenenUNKNOWN Members of the Consensus Conference
Jul 17, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·F RinaldiP Gallo
Jul 20, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Monica Falautano
Oct 23, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Giancarlo Comi
May 4, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·D ObradovicS Obradovic
Apr 19, 2008·Journal of the International Neuropsychological Society : JINS·Peter A ArnettBrian P Ahlstrom
Jan 9, 2009·Journal of the International Neuropsychological Society : JINS·Christopher ChristodoulouLauren B Krupp
Feb 20, 2010·Journal of the International Neuropsychological Society : JINS·Julie OuelletPierre Duquette
Jan 20, 2011·The Clinical Neuropsychologist·Fiona H Barwick, Peter A Arnett
Oct 13, 2009·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Angela M BodlingSharon G Lynch
Jan 8, 2013·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Mathias SundgrenTom Brismar
Aug 5, 2009·Health Education Research·Eynat Shevil, Marcia Finlayson
Aug 24, 2012·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Owen B White, Joanne Fielding
Jan 7, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C SmestadE G Celius
Oct 20, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·K van der HieleL H Visser
Feb 4, 2011·BMC Neurology·Karine Baumstarck-BarrauPascal Auquier
Mar 9, 2012·BMC Neurology·Dana HorakovaOndrej Dolezal
Jul 31, 2013·BMC Neurology·Carmela LeoneFrancesco Patti
Mar 26, 2009·BMC Neurology·Femke A H van der LindenBernard M J Uitdehaag
Feb 8, 2014·Neurophysiologie clinique = Clinical neurophysiology·G AllaliP H Lalive
May 17, 2014·Neurodegenerative Disease Management·Vargas Gray, Peter Arnett
Mar 4, 2014·Multiple Sclerosis International·Silvia Messina, Francesco Patti
Dec 18, 2007·Journal of Neurology·C RussoUmberto Aguglia
Apr 23, 2013·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Mark S FreedmanUNKNOWN Canadian Multiple Sclerosis Working Group
Feb 16, 2011·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·L A S WalkerA M Smith

❮ Previous
Next ❯

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