Multiple sclerosis risk pathways differ in Caucasian and Chinese populations

Journal of Neuroimmunology
Guiyou LiuJunwei Hao

Abstract

Large-scale genome-wide association study (GWAS) datasets provide strong support for investigations of the mechanisms underlying multiple sclerosis (MS) by using pathway analysis methods. In our recent study, we conducted a three-stage pathway analysis of GWAS and expression datasets. After identifying 15 shared MS pathways in separate MS GWAS datasets, we found that dysregulated MS genes were significantly enriched in 10 of the 15 MS risk pathways. Evidence showed that 17%-30% of genes are differentially expressed among individual ethnic populations. We then verified the potential disruption of genes in the 10 MS risk pathways cited above in Chinese MS patients. Here, we investigated potential up- and down-regulation of 42 MS genes in these 10 MS risk pathways using 132 Chinese MS patients and 76 healthy control subjects. We then identified 31 differentially expressed genes in Chinese MS patients compared to healthy control subjects. Moreover, the expression patterns of 28 of these genes were consistent with those obtained from Caucasian (European and American) MS patients, although 14 genes differed from the latter group's. Our results provide clinically useful clues about the link between these risk genes and MS susceptibili...Continue Reading

Citations

Sep 27, 2018·Current Drug Metabolism·Yang HuLiang Cheng
Jun 11, 2020·Annals of Clinical and Translational Neurology·Lin ZhaoAlexander Y Lau
Apr 5, 2019·Computational and Mathematical Methods in Medicine·Hongmin CaiLi Li
Jul 29, 2020·Frontiers in Genetics·Zhu TianZhiyun Wang
Jan 15, 2018·Journal of Alzheimer's Disease : JAD·Guiyou LiuQinghua Jiang
Feb 5, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Lu XuDongsheng Fan

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