Multiple Sclerosis: Shall We Target CD33?

Genes
Vasileios SiokasEfthimios Dardiotis

Abstract

Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS). Myeloid lineage cells (microglia and macrophages) may participate in the pathogenic mechanisms leading to MS. CD33 is a transmembrane receptor, mainly expressed by myeloid lineage cells. CD33 rs3865444 is a promoter variant previously associated with Alzheimer's disease, whose role in MS remains obscure. To assess the role of CD33 rs3865444 in MS risk. We genotyped 1396 patients with MS and 400 healthy controls for the presence of the CD33 rs3865444 variant. Odds ratios (ORs) with the respective 95% confidence intervals (CIs), were calculated with the SNPStats software, assuming five genetic models (co-dominant, dominant, recessive, over-dominant, and log-additive), with the G allele as the reference allele. The value of 0.05 was set as the threshold for statistical significance. CD33 rs3865444 was associated with MS risk in the dominant (GG vs. GT + TT; OR (95% C.I.) = 0.79 (0.63-0.99), p = 0.041) and the over-dominant (GG + TT vs. GT; OR (95% C.I.) = 0.77 (0.61-0.97), p = 0.03) modes of inheritance. Given that the GG genotype was more frequent and the GT genotype was less frequent in MS patients compared to controls-while the observed frequency ...Continue Reading

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Citations

Feb 15, 2021·Neuroscience Letters·Vasileios SiokasEfthimios Dardiotis
Feb 11, 2021·Journal of Clinical Medicine·Athina-Maria AloizouEfthimios Dardiotis
Jan 28, 2021·Journal of Clinical Medicine·Vasileios SiokasEfthimios Dardiotis
Mar 1, 2021·Reviews in the Neurosciences·Athina-Maria AloizouEfthimios Dardiotis

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Software Mentioned

SDS
SNPStats
CaTS Power Calculator

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