PMID: 8964905May 1, 1996Paper

Multiple sclerosis: the proinflammatory cytokines lymphotoxin-alpha and tumour necrosis factor-alpha are upregulated in cerebrospinal fluid mononuclear cells

Journal of Neuroimmunology
D MatuseviciusH Link

Abstract

Lymphotoxin-alpha (LT-alpha) and tumour necrosis factor-alpha (TNF-alpha) promote inflammation in autoimmune diseases and have been detected in the multiple sclerosis (MS) brain lesions and blood, suggesting these cytokines are also present in the cerebrospinal fluid (CSF). To study this, mononuclear cells (MNC) were examined for transcripts of LT-alpha and TNF-alpha, using in situ hybridization (ISH) with synthetic oligonucleotide probes. Most patients with MS had LT-alpha and TNF-alpha mRNA-expressing MNC in their CSF at mean frequencies of about 1/2800 cells for both cytokines. Numbers were dramatically higher than in the paired blood specimens. Control patients with other inflammatory neurological diseases (OIND) also had LT-alpha and TNF-alpha mRNA-expressing cells in CSF but at mean frequencies of only 1/36,000 and 1/18,000 cells, respectively. In blood, levels were similar in OIND and MS. To elucidate the influence of myelin antigen stimulation on LT-alpha and TNF-alpha expression, MNC were cultivated with or without myelin basic protein. Strongly elevated levels of MBP-reactive TNF-alpha mRNA-expressing cells were detected in the MS patients' CSF, in particular when examined during clinical exacerbations, as well as MBP...Continue Reading

References

Aug 15, 1991·The New England Journal of Medicine·M K Sharief, R Hentges
Aug 1, 1991·Journal of the Neurological Sciences·N TsukadaK Yone
Mar 1, 1991·The Journal of Clinical Investigation·K SelmajC F Brosnan
Apr 1, 1991·Journal of Neuroimmunology·D MaimoneA T Reder
Apr 1, 1986·Journal of Neuroimmunology·D R Hampson, S E Poduslo
Dec 1, 1989·Annals of Neurology·D M FranciottaG V Melzi d'Eril
Oct 1, 1989·Journal of Neuroimmunology·B Cannella, C S Raine
Apr 1, 1988·Annals of Neurology·K W Selmaj, C S Raine
Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Oct 1, 1994·The Journal of Clinical Investigation·R M PopeS A Ness
Nov 27, 1964·Science·E H HESS

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Citations

Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Krishnan Sriram, James P O'Callaghan
Mar 28, 2001·The Annals of Thoracic Surgery·T KuniharaK Yasuda
Nov 5, 1998·Veterinary Immunology and Immunopathology·A GröneW Baumgärtner
Sep 3, 1998·Journal of Neuroimmunology·P A CalabresiE P Cowan
Dec 1, 1999·Annals of the Rheumatic Diseases·C LockL Steinman
Feb 22, 2011·Neuroepidemiology·Julián Benito-León
Sep 18, 2012·Journal of Neuroinflammation·Jeppe Romme ChristensenFinn Sellebjerg
Feb 14, 2007·Acta Neurologica Scandinavica·E Kamali-SarvestaniB Gharesi-Fard
Jul 2, 2005·Expert Opinion on Investigational Drugs·E G Spack
Sep 19, 2008·Expert Opinion on Drug Metabolism & Toxicology·Gaylia Jean Harry, Andrew D Kraft
May 21, 1999·Multiple Sclerosis : Clinical and Laboratory Research·D MatuseviciusH Link
Oct 8, 1998·Multiple Sclerosis : Clinical and Laboratory Research·A T RederA M Porrini
Jan 22, 2008·Journal of Neuroimmunology·Heather A IoccaJenny P-Y Ting
Nov 28, 2018·Scientific Reports·Vicki E MaltbyJeannette Lechner-Scott
Jan 15, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·I V SmaginaL P Galaktionova
Dec 24, 1997·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·L F JarskogJ H Gilmore
Mar 4, 2005·Brain : a Journal of Neurology·Takaaki IshizuJun-ichi Kira
Apr 2, 2004·Journal of Neuropathology and Experimental Neurology·Katarzyna BiernackiJack P Antel
Jan 13, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mathilde FauconnierValérie F J Quesniaux
Apr 13, 1999·The American Journal of Physiology·J B DicksteinJ B Hay
Oct 18, 2020·Cells·Diego FresegnaAntonietta Gentile
Jun 30, 2021·Neurochemistry International·Ivan A LindhoutAndis Klegeris
Jul 27, 2021·Frontiers in Immunology·Fabian RichterRoman Fischer

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