Multiple sequential light and laser sources to activate aminolevulinic acid in the treatment of photodamage: A retrospective study

Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology
Daniel P FriedmannIsabella Guiha

Abstract

The aim of this study was to retrospectively evaluate photodynamic therapy (PDT) with aminolevulinic acid (ALA) for cutaneous photorejuvenation using blue light sequentially with red light, pulsed-dye laser (PDL), and/or intense pulsed light (IPL). Ninety-six patients (121 treatments) had photodamage treated with field-directed ALA-PDT from 2001 to 2010 in this single-center study. Treatments were performed with blue light + PDL, blue light + IPL, blue light + PDL + IPL, or blue light + red light + PDL + IPL. Outcome measures were obtained via telephone questionnaire and graded on a four-point scale. There were no significant differences in patient-reported improvement in photodamage, overall skin quality, and postprocedure adverse events between treatment arms. However, number of patients in the blue light + red light + PDL + IPL group was markedly smaller (n = 2) than that in the other groups (n = 14-46). Although results showed a trend toward greater efficacy with similar tolerability using multiple, sequential light and laser sources with ALA-PDT for photorejuvenation, the potential for recall bias and widely disparate number of patients between treatment groups and follow-up times between patients severely limit this retro...Continue Reading

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Citations

Oct 25, 2017·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Mitchel P Goldman
Mar 25, 2019·Lasers in Medical Science·Michelle Barreto RequenaPriscila Fernanda Campos de Menezes
Apr 30, 2016·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Daniel P Friedmann, Mitchel P Goldman
Aug 11, 2019·International Journal of Molecular Sciences·Sarah Raquel De AnnunzioCarla Raquel Fontana

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