Multiple Sessions of Transcranial Direct Current Stimulation (tDCS) Reduced Craving and Relapses for Alcohol Use: A Randomized Placebo-Controlled Trial in Alcohol Use Disorder

Frontiers in Pharmacology
Jaisa KlaussEster Miyuki Nakamura-Palacios

Abstract

Background: Transcranial direct current stimulation (tDCS), a non-invasive brain stimulation technique, has been studied as an adjunctive therapeutic agent for alcohol dependence. In a previous study, we showed that five consecutive sessions of tDCS applied bilaterally over the dorsolateral prefrontal cortex (dlPFC) reduced relapse to the use of alcohol in alcohol use disorder (AUD) outpatients. However, no changes on craving scores were observed. In the present study, we investigated if an extended number of sessions of the same intervention would reduce craving and relapses for alcohol use in AUD inpatients. Methods: Thus, a randomized, double-blind, sham-controlled, clinical trial with parallel arms was conducted (https://clinicaltrials.gov/ct2/show/NCT02091284). AUD patients from two private and one public clinics for treatment of drug dependence were randomly allocated to two groups: real tDCS (5 × 7 cm2, 2 mA, for 20 min, cathodal over the left dlPFC, and anodal over the right dlPFC) and sham-tDCS. Real or sham-tDCS was applied once a day, every other day, in a total of 10 sessions. Craving was monitored by a 5-item obsessive compulsive drinking scale once a week (one time before, three times during and once after brain s...Continue Reading

Associated Clinical Trials

Mar 19, 2014·Ester Miyuki Nakamura-PalaciosEster Miyuki Nakamura-Palacios
Mar 19, 2014·Ester Miyuki Nakamura-PalaciosEster Miyuki Nakamura-Palacios

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Citations

Aug 28, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Noah S PhilipColleen A Hanlon
Sep 7, 2019·Nutrients·Rachel C AdamsNatalia S Lawrence
Oct 6, 2020·Frontiers in Neuroscience·Chiara ZucchellaStefano Tamburin
Nov 5, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Hyun Joon Kim, Nyeonju Kang
Jul 28, 2020·The International Journal of Neuropsychopharmacology·Felipe FregniUNKNOWN Neuromodulation Center Working Group
Nov 13, 2019·Progress in Neuro-psychopharmacology & Biological Psychiatry·Juliana Teti MayerDjamila Bennabi
Aug 20, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ahmet O CeceliRita Z Goldstein

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Clinical Trials Mentioned

NCT02091284

Software Mentioned

GraphPad Prism
Power
SPSS Statistics
SPSS

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Alcohol Use Disorder

Alcohol use disorder involves a pattern of alcohol consumption that includes compulsive use and a loss of control over intake of alcohol. The impact on physical health, socioeconomic factors, and psychiatric health is profound. Find the latest research on alcohol use disorder here.