Multiple sevoflurane exposures in infant monkeys do not impact the mother-infant bond

Neurotoxicology and Teratology
Jessica RaperMaria C Alvarado

Abstract

Exposure to general anesthesia during the postnatal period is associated with death of brain cells as well as long-term impairments in cognitive and emotional behavior in animal models. These models are critical for investigating mechanisms of pediatric anesthetic neurotoxicity as well as for testing potential strategies for preventing or mitigating this toxicity. Control conditions for anesthesia exposure involve separation of conscious infants from their mothers for variable periods of time, which could have its own effect on subsequent behavior because of stress to the mother and/or infant as a consequence of separation.We are conducting a long-term study of infant rhesus monkeys exposed three times for 4h each to sevoflurane anesthesia during the first six postnatal weeks, with a comparison condition of control infant monkeys that undergo brief maternal separations on the same schedule, to equate the period of time each infant is conscious and separated from its mother. Because mothers are separated from their infants longer for infants in the anesthesia condition, this could modify maternal behavior toward the infant, which may influence subsequent socioemotional behavior in the infants. In this study, we analyzed maternal...Continue Reading

References

Jan 1, 1967·Animal Behaviour·R A Hinde, Y Spencer-Booth
Feb 13, 2001·Biological Psychiatry·J K RillingC D Kilts
Aug 8, 2001·Folia primatologica; international journal of primatology·G R Brown
Jan 23, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·M D BaumanD G Amaral
Nov 7, 2006·Behavioural Brain Research·Anne-Pierre S Goursaud, Jocelyne Bachevalier
Apr 12, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·William SlikkerCheng Wang
Mar 18, 2010·Anesthesiology·Ansgar M BrambrinkJohn W Olney
Jun 18, 2011·Biological Psychiatry·Heather C Brenhouse, Susan L Andersen
Oct 5, 2011·Pediatrics·Randall P FlickDavid O Warner
Jun 12, 2012·Developmental Cognitive Neuroscience·Lisa A ParrMar M Sánchez
Jun 10, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Greg StratmannSimona Ghetti
Feb 26, 2015·The New England Journal of Medicine·Bob A RappaportBeverley A Orser
Jul 25, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Fang LiuXianlin Han
Sep 12, 2015·The Lancet. Psychiatry·Colette Davidson

❮ Previous
Next ❯

Citations

Aug 27, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Julie K DrobishMaryellen F Eckenhoff
Oct 19, 2016·Nature Reviews. Neuroscience·Laszlo Vutskits, Zhongcong Xie
Mar 10, 2017·Current Opinion in Anaesthesiology·Laszlo Vutskits, Andrew Davidson
Jun 1, 2017·Current Opinion in Anaesthesiology·Federico BilottaShaun E Gruenbaum
Apr 5, 2018·Frontiers in Neurology·W Alan C MutchM Ruth Graham
Jun 3, 2017·British Journal of Anaesthesia·M C AlvaradoM G Baxter

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Brain Circuits in Emotional Learning

The neuronal circuits within the cortico-limbic brain regions form networks that mediate emotional behavior. Areas specific to emotional learning include the basal amygdala and sublenticular extended amygdala region along with a supplemental motor area. Discover the latest research on brain circuits in emotional learning here.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.