Multiple signals evoked by unisensory stimulation converge onto cerebellar granule and Purkinje cells in mice.

Communications Biology
M. ShimutaTaro Ishikawa

Abstract

The cerebellum receives signals directly from peripheral sensory systems and indirectly from the neocortex. Even a single tactile stimulus can activate both of these pathways. Here we report how these different types of signals are integrated in the cerebellar cortex. We used in vivo whole-cell recordings from granule cells and unit recordings from Purkinje cells in mice in which primary somatosensory cortex (S1) could be optogenetically inhibited. Tactile stimulation of the upper lip produced two-phase granule cell responses (with latencies of ~8 ms and 29 ms), for which only the late phase was S1 dependent. In Purkinje cells, complex spikes and the late phase of simple spikes were S1 dependent. These results indicate that individual granule cells combine convergent inputs from the periphery and neocortex and send their outputs to Purkinje cells, which then integrate those signals with climbing fiber signals from the neocortex.

References

Oct 1, 1974·Physiological Reviews·G I Allen, N Tsukahara
Jun 1, 1969·The Journal of Physiology·D Marr
Sep 15, 1998·Trends in Neurosciences·C I De ZeeuwT J Ruigrok
Aug 24, 1999·The European Journal of Neuroscience·B P VosE De Schutter
Apr 23, 2004·Nature·Paul ChaddertonMichael Häusser
Oct 8, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Izumi Sugihara, Yoshikazu Shinoda
Nov 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Henrik Jörntell, Carl-Fredrik Ekerot
Jul 7, 2007·Journal of Neurophysiology·Fredrik Bengtsson, Henrik Jörntell
Nov 5, 2008·Frontiers in Neuroscience·Trygve B Leergaard, Jan G Bjaalie
Dec 17, 2008·Journal of Neurophysiology·Shyam DiwakarEgidio D'Angelo
Jan 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Fredrik Bengtsson, Henrik Jörntell
Aug 21, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hana RosDavid A McCormick
Dec 10, 2009·Nature Reviews. Neuroscience·Paul DeanHenrik Jörntell
Nov 27, 2010·Science·Ferenc MatyasCarl C H Petersen
Dec 15, 2010·Frontiers in Neuroscience·Nobuaki Tamamaki, Ryohei Tomioka
Oct 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sylvain ChauvetteIgor Timofeev
Nov 9, 2011·Frontiers in Integrative Neuroscience·Laurens W J BosmanChris I De Zeeuw
Dec 14, 2011·Neuron·Yoshinao Kajikawa, Charles E Schroeder
Dec 27, 2011·Nature·Abigail L Person, Indira M Raman
Aug 10, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ian DuguidMichael Häusser
Apr 13, 2013·Trends in Cognitive Sciences·Andreea C BostanPeter L Strick
Aug 27, 2013·Nature Neuroscience·Majid H MohajeraniTimothy H Murphy
Dec 24, 2013·Neuron·Zengcai V GuoKarel Svoboda
Jul 30, 2014·Nature Neuroscience·Rémi D ProvilleClément Léna
Feb 6, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marius PachitariuNicholas A Lesica
Mar 4, 2015·Nature·Nuo LiKarel Svoboda
Mar 31, 2015·Nature Neuroscience·François P ChabrolDavid A DiGregorio
May 26, 2015·Neuron·Satoshi ManitaMasanori Murayama
Jun 22, 2015·Trends in Neurosciences·Anton Spanne, Henrik Jörntell
Oct 4, 2015·Proceedings of the National Academy of Sciences of the United States of America·Ian DuguidMichael Häusser
Dec 30, 2015·ELife·Taro IshikawaMichael Häusser
Feb 27, 2016·The Journal of Physiology·Antonin BlotClément Léna

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Citations

Dec 29, 2020·Cell Reports·Shinichiro TsutsumiMichael Häusser
Sep 30, 2021·The Journal of Comparative Neurology·Cristian Gutiérrez-IbáñezDouglas R Wylie

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